Uterine tumour resembling an ovarian sex cord tumour

• Published in: Journal of clinical pathology Vol. 58; no. 8; pp. 888 - 890
• Main Authors: Sutak, J, Lazic, D, Cullimore, J E
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.08.2005; BMJ; BMJ Publishing Group LTD; Copyright 2005 Journal of Clinical Pathology
• Subjects: Aged; Biological and medical sciences; Biomarkers, Tumor - metabolism; Case Reports; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; endometrial stromal sarcoma; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Hysterectomy; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Neprilysin - metabolism; Ovarian Neoplasms - pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Sarcoma, Endometrial Stromal - metabolism; Sarcoma, Endometrial Stromal - pathology; sex cord differentiation; Sex Cord-Gonadal Stromal Tumors - metabolism; Sex Cord-Gonadal Stromal Tumors - pathology; Smooth muscle; Tumors; uterine tumour resembling an ovarian sex cord tumour; uterus; UTROSCT; United Kingdom > UK; California; Ovarian diseases; Anatomic pathology; Uterus; Female genital system; Sex; Female genital diseases; Ovarian tumor
• ISSN: 0021-9746; 1472-4146
• DOI: 10.1136/jcp.2004.022616

Endometrial stromal sarcomas account for 0.25% of all uterine malignancies. These tumours were originally divided into low grade and high grade stromal sarcomas, but the recent World Health Organisation classification (2003) recognises low grade stromal sarcoma and undifferentiated endometrial sarcoma. Low grade sarcomas may exhibit other forms of differentiation, including smooth muscle and sex cord differentiation. In the latter form, the tumour contains epithelial-like or sex cord-like elements often with epithelioid appearance, arranged in nests, cords, trabeculae, solid, or tubular structures. If this element predominates, the tumour is considered to be a uterine tumour resembling ovarian sex cord tumour, and may cause diagnostic difficulties. This case report describes the histological and immunohistochemical features of a uterine stromal sarcoma showing exclusively a pattern reminiscent of ovarian sex cord tumour.