Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI
To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow ab...
Saved in:
| Published in | Thorax Vol. 76; no. 2; pp. 178 - 181 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BMJ Publishing Group Ltd and British Thoracic Society
01.02.2021
BMJ Publishing Group LTD BMJ Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0040-6376 1468-3296 1468-3296 |
| DOI | 10.1136/thoraxjnl-2020-214924 |
Cover
Loading…
| Abstract | To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema. |
|---|---|
| AbstractList | To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema. To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema.To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema. |
| Author | Mugler, John Lin, Zixuan Huang, Yong Altes, Talissa Patrie, James Tustison, Nicholas Cassani, Joanne Manichaikul, Ani W Mata, Jaime Nunoo-Asare, Roselove N Shim, Y Michael Qing, Kun Tafti, Sina Myc, Lukasz Obaida, Zaid He, Mu Miller, Grady Wilson Ropp, Alan M |
| AuthorAffiliation | 5 Radiology , University of Missouri , Columbia , Missouri , USA 2 Radiology , University of Virginia School of Medicine , Charlottesville , Virginia , USA 4 Public Health , University of Virginia School of Medicine , Charlottesville , Virginia , USA 6 Physics , University of Virginia , Charlottesville , Virginia , USA 1 Medicine , University of Virginia School of Medicine , Charlottesville , Virginia , USA 3 Biomedical Engineering , University of Virginia , Charlottesville , Virginia , USA |
| AuthorAffiliation_xml | – name: 1 Medicine , University of Virginia School of Medicine , Charlottesville , Virginia , USA – name: 2 Radiology , University of Virginia School of Medicine , Charlottesville , Virginia , USA – name: 3 Biomedical Engineering , University of Virginia , Charlottesville , Virginia , USA – name: 4 Public Health , University of Virginia School of Medicine , Charlottesville , Virginia , USA – name: 5 Radiology , University of Missouri , Columbia , Missouri , USA – name: 6 Physics , University of Virginia , Charlottesville , Virginia , USA |
| Author_xml | – sequence: 1 givenname: Lukasz surname: Myc fullname: Myc, Lukasz organization: Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 2 givenname: Kun orcidid: 0000-0001-5784-291X surname: Qing fullname: Qing, Kun organization: Radiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 3 givenname: Mu surname: He fullname: He, Mu organization: Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 4 givenname: Nicholas surname: Tustison fullname: Tustison, Nicholas organization: Radiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 5 givenname: Zixuan surname: Lin fullname: Lin, Zixuan organization: Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA – sequence: 6 givenname: Ani W surname: Manichaikul fullname: Manichaikul, Ani W organization: Public Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 7 givenname: James surname: Patrie fullname: Patrie, James organization: Public Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 8 givenname: Joanne surname: Cassani fullname: Cassani, Joanne organization: Radiology, University of Missouri, Columbia, Missouri, USA – sequence: 9 givenname: Roselove N surname: Nunoo-Asare fullname: Nunoo-Asare, Roselove N organization: Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 10 givenname: Yong surname: Huang fullname: Huang, Yong organization: Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 11 givenname: Zaid surname: Obaida fullname: Obaida, Zaid organization: Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 12 givenname: Sina surname: Tafti fullname: Tafti, Sina organization: Physics, University of Virginia, Charlottesville, Virginia, USA – sequence: 13 givenname: Alan M surname: Ropp fullname: Ropp, Alan M organization: Radiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 14 givenname: Grady Wilson surname: Miller fullname: Miller, Grady Wilson organization: Radiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 15 givenname: Jaime surname: Mata fullname: Mata, Jaime organization: Radiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 16 givenname: Talissa surname: Altes fullname: Altes, Talissa organization: Radiology, University of Missouri, Columbia, Missouri, USA – sequence: 17 givenname: John surname: Mugler fullname: Mugler, John organization: Radiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA – sequence: 18 givenname: Y Michael orcidid: 0000-0002-3780-3371 surname: Shim fullname: Shim, Y Michael email: yss6n@virginia.edu organization: Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33139449$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc1uEzEURi1URNPCI4AsselmwL_jsZCQUAq0UlERgg0by-PcyTia2IM9Kenb4zYlQBfAyguf8_lef0foIMQACD2l5AWlvH459THZ7SoMFSOMVIwKzcQDNKOibirOdH2AZoQIUtVc1YfoKOcVIaShVD1Ch5xTroXQM_R13ttk3QTJZzv5GHDs8NJmDFvX27AE7AOeX348xd_91OOFzzkOV7Coxt5mwP31CGmMgy06LPAWypQVZRp_-HT-GD3s7JDhyd15jL68e_t5flZdXL4_n7-5qFrJ2FQpSWvgruVglXK1YAQEdLZhUusOpGpa1shWN1oXhANzlgHX0BEFonVK8mP0epc7bto1LByEKdnBjMmvbbo20Xrz503wvVnGK6MaKhvNS8DJXUCK3zaQJ7P22cEw2ABxkw0TUnEiaqEK-vweuoqbFMp6hSp5WlBGC_Xs94n2o_z89gLIHeBSzDlBt0coMTf1mn295qZes6u3eK_uec5Pt7WVxfzwT5vs7Ha9-u8H6S9lv-rfnR-HAs6R |
| CitedBy_id | crossref_primary_10_1016_j_resinv_2024_08_014 crossref_primary_10_1148_ryct_220096 crossref_primary_10_1002_mef2_73 crossref_primary_10_1148_radiol_2021211524 crossref_primary_10_3390_molecules28010011 crossref_primary_10_52775_1810_200X_2024_102_2_91_109 crossref_primary_10_1016_j_chest_2023_03_024 crossref_primary_10_2147_COPD_S324388 crossref_primary_10_33590_emj_UJRW1078 crossref_primary_10_3389_fmed_2024_1342499 crossref_primary_10_1002_mrm_29501 crossref_primary_10_1002_jmri_27662 crossref_primary_10_1002_mrm_28908 crossref_primary_10_1183_20734735_0272_2022 crossref_primary_10_1097_RLI_0000000000001017 crossref_primary_10_1080_17476348_2023_2241355 |
| Cites_doi | 10.1186/s12931-014-0127-9 10.1148/radiol.2382042196 10.14814/phy2.12068 10.1164/rccm.201311-2006PP 10.1378/chest.10-2948 10.1186/s40169-019-0231-z 10.1002/nbm.3179 10.1016/j.bbrc.2011.09.006 10.1002/jmri.22738 10.1016/j.acra.2018.05.025 |
| ContentType | Journal Article |
| Copyright | Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021 |
| Copyright_xml | – notice: Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. – notice: 2021 Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2021 |
| DBID | 9YT ACMMV AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR BTHHO CCPQU FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM |
| DOI | 10.1136/thoraxjnl-2020-214924 |
| DatabaseName | BMJ Open Access Journals BMJ Journals:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central BMJ Journals ProQuest One Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) Medical Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete ProQuest Health & Medical Research Collection Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) BMJ Journals Health & Medical Research Collection ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | CrossRef ProQuest One Academic Middle East (New) MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: ACMMV name: BMJ Journals:Open Access url: https://journals.bmj.com/ sourceTypes: Publisher – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1468-3296 |
| EndPage | 181 |
| ExternalDocumentID | PMC7815893 33139449 10_1136_thoraxjnl_2020_214924 thoraxjnl |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: National Cancer Institute grantid: CA172595 funderid: http://dx.doi.org/10.13039/100000054 – fundername: National Heart, Lung, and Blood Institute grantid: HL091127; HL109618; HL132177; HL132287 funderid: http://dx.doi.org/10.13039/100000050 – fundername: National Institutes of Health grantid: S10OD018079 funderid: http://dx.doi.org/10.13039/100000002 – fundername: NHLBI NIH HHS grantid: K08 HL091127 – fundername: NIH HHS grantid: S10 OD018079 – fundername: NHLBI NIH HHS grantid: R01 HL132177 – fundername: NHLBI NIH HHS grantid: R01 HL109618 – fundername: NHLBI NIH HHS grantid: R01 HL132287 – fundername: NCI NIH HHS grantid: R01 CA172595 – fundername: ; grantid: CA172595 – fundername: ; grantid: HL091127; HL109618; HL132177; HL132287 – fundername: ; grantid: S10OD018079 |
| GroupedDBID | --- .55 .GJ .VT 08G 0R~ 123 18M 29Q 2WC 354 39C 3O- 4.4 40O 53G 5RE 5VS 6PF 7X7 7~S 88E 8F7 8FI 8FJ 8R4 8R5 9YT AAHLL AAKAS AAOJX AAWJN AAWTL AAYEP ABAAH ABJNI ABKDF ABMQD ABOCM ABTFR ABUWG ABVAJ ACGFO ACGFS ACGTL ACHTP ACMFJ ACMMV ACOAB ACOFX ACQSR ACTZY ADBBV ADCEG ADZCM AENEX AFKRA AFWFF AGQPQ AHMBA AHNKE AHQMW AJYBZ ALIPV ALMA_UNASSIGNED_HOLDINGS ASPBG AVWKF AZFZN BAWUL BENPR BLJBA BOMFT BPHCQ BTFSW BTHHO BVXVI C45 CAG CCPQU COF CS3 CXRWF DIK DU5 E3Z EBS EJD F5P FEDTE FYUFA GX1 H13 HAJ HMCUK HVGLF HYE HZ~ IAO IEA IH2 IHR IOF ITC J5H KQ8 L7B M1P N4W N9A NTWIH NXWIF O9- OK1 OVD P2P PHGZT PQQKQ PROAC PSQYO Q2X R53 RHI RMJ RPM RV8 TEORI TR2 UAW UKHRP UYXKK V24 VM9 VVN W8F WH7 X7M YFH YOC YQY ZCG ZGI AAYXX ACQHZ ADGHP AERUA CITATION PHGZM CGR CUY CVF ECM EIF NPM PJZUB PPXIY 3V. 7XB 8FK K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-b522t-7516e3cb3ea77c6420e4efa82599fe578b285b9899b3e3e2ca2e39ef07e4bc753 |
| IEDL.DBID | 9YT |
| ISSN | 0040-6376 1468-3296 |
| IngestDate | Thu Aug 21 18:21:24 EDT 2025 Thu Sep 04 17:33:10 EDT 2025 Fri Jul 25 20:49:26 EDT 2025 Mon Jul 21 05:51:00 EDT 2025 Tue Jul 01 02:00:42 EDT 2025 Thu Apr 24 23:03:12 EDT 2025 Thu Apr 24 22:49:52 EDT 2025 Thu Apr 24 22:49:23 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | respiratory measurement COPD ÀÜ mechanisms lung physiology imaging/CT MRI etc COPD pathology emphysema |
| Language | English |
| License | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b522t-7516e3cb3ea77c6420e4efa82599fe578b285b9899b3e3e2ca2e39ef07e4bc753 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-3780-3371 0000-0001-5784-291X |
| OpenAccessLink | http://dx.doi.org/10.1136/thoraxjnl-2020-214924 |
| PMID | 33139449 |
| PQID | 2478194121 |
| PQPubID | 2041050 |
| PageCount | 4 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7815893 proquest_miscellaneous_2457304647 proquest_journals_2478194121 pubmed_primary_33139449 crossref_primary_10_1136_thoraxjnl_2020_214924 crossref_citationtrail_10_1136_thoraxjnl_2020_214924 bmj_primary_10_1136_thoraxjnl_2020_214924 bmj_journals_10_1136_thoraxjnl_2020_214924 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-02-01 |
| PublicationDateYYYYMMDD | 2021-02-01 |
| PublicationDate_xml | – month: 02 year: 2021 text: 2021-02-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London – name: BMA House, Tavistock Square, London, WC1H 9JR |
| PublicationTitle | Thorax |
| PublicationTitleAbbrev | Thorax |
| PublicationTitleAlternate | Thorax |
| PublicationYear | 2021 |
| Publisher | BMJ Publishing Group Ltd and British Thoracic Society BMJ Publishing Group LTD BMJ Publishing Group |
| Publisher_xml | – name: BMJ Publishing Group Ltd and British Thoracic Society – name: BMJ Publishing Group LTD – name: BMJ Publishing Group |
| References | Carolan, Hughes, Morrow (R2) 2014; 15 Madani, Zanen, de Maertelaer (R10) 2006; 238 Tustison, Avants, Flors (R8) 2011; 34 Qing, Mugler, Altes (R4) 2014; 27 Kirby, Ouriadov, Svenningsen (R5) 2014; 2 Kim, Han, Vance (R9) 2011; 140 Vestbo, Agusti, Wouters (R1) 2014; 189 Qing, Tustison, Mugler (R6) 2019; 26 Paige, Burdick, Kim (R3) 2011; 413 Myc, Shim, Laubach (R7) 2019; 8 Kirby, Ouriadov, Svenningsen 2014; 2 Qing, Mugler, Altes 2014; 27 Qing, Tustison, Mugler 2019; 26 Myc, Shim, Laubach 2019; 8 Kim, Han, Vance 2011; 140 Vestbo, Agusti, Wouters 2014; 189 Tustison, Avants, Flors 2011; 34 Carolan, Hughes, Morrow 2014; 15 Madani, Zanen, de Maertelaer 2006; 238 Paige, Burdick, Kim 2011; 413 2024092104051364000_76.2.178.4 Qing (2024092104051364000_76.2.178.6) 2019; 26 2024092104051364000_76.2.178.3 Kirby (2024092104051364000_76.2.178.5) 2014; 2 2024092104051364000_76.2.178.2 2024092104051364000_76.2.178.1 2024092104051364000_76.2.178.10 2024092104051364000_76.2.178.8 Myc (2024092104051364000_76.2.178.7) 2019; 8 2024092104051364000_76.2.178.9 |
| References_xml | – volume: 15 year: 2014 ident: R2 article-title: The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes publication-title: Respir Res doi: 10.1186/s12931-014-0127-9 – volume: 238 start-page: 1036 year: 2006 ident: R10 article-title: Pulmonary emphysema: objective quantification at multi-detector row CT--comparison with macroscopic and microscopic morphometry publication-title: Radiology doi: 10.1148/radiol.2382042196 – volume: 2 year: 2014 ident: R5 article-title: Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers publication-title: Physiol Rep doi: 10.14814/phy2.12068 – volume: 189 start-page: 1022 year: 2014 ident: R1 article-title: Should we view chronic obstructive pulmonary disease differently after eclipse? a clinical perspective from the study Team publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201311-2006PP – volume: 140 start-page: 626 year: 2011 ident: R9 article-title: The chronic bronchitic phenotype of COPD: an analysis of the COPDGene study publication-title: Chest doi: 10.1378/chest.10-2948 – volume: 8 year: 2019 ident: R7 article-title: Role of medical and molecular imaging in COPD publication-title: Clin Transl Med doi: 10.1186/s40169-019-0231-z – volume: 27 start-page: 1490 year: 2014 ident: R4 article-title: Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI publication-title: NMR Biomed doi: 10.1002/nbm.3179 – volume: 413 start-page: 588 year: 2011 ident: R3 article-title: Pilot analysis of the plasma metabolite profiles associated with emphysematous chronic obstructive pulmonary disease phenotype publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2011.09.006 – volume: 34 start-page: 831 year: 2011 ident: R8 article-title: Ventilation-based segmentation of the lungs using hyperpolarized (3)He MRI publication-title: J Magn Reson Imaging doi: 10.1002/jmri.22738 – volume: 26 start-page: 326 year: 2019 ident: R6 article-title: Probing changes in lung physiology in COPD using CT, perfusion MRI, and hyperpolarized xenon-129 MRI publication-title: Acad Radiol doi: 10.1016/j.acra.2018.05.025 – volume: 238 start-page: 1036 year: 2006 article-title: Pulmonary emphysema: objective quantification at multi-detector row CT--comparison with macroscopic and microscopic morphometry publication-title: Radiology doi: 10.1148/radiol.2382042196 – volume: 413 start-page: 588 year: 2011 article-title: Pilot analysis of the plasma metabolite profiles associated with emphysematous chronic obstructive pulmonary disease phenotype publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2011.09.006 – volume: 26 start-page: 326 year: 2019 article-title: Probing changes in lung physiology in COPD using CT, perfusion MRI, and hyperpolarized xenon-129 MRI publication-title: Acad Radiol doi: 10.1016/j.acra.2018.05.025 – volume: 27 start-page: 1490 year: 2014 article-title: Assessment of lung function in asthma and COPD using hyperpolarized 129Xe chemical shift saturation recovery spectroscopy and dissolved-phase MRI publication-title: NMR Biomed doi: 10.1002/nbm.3179 – volume: 189 start-page: 1022 year: 2014 article-title: Should we view chronic obstructive pulmonary disease differently after eclipse? a clinical perspective from the study Team publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201311-2006PP – volume: 140 start-page: 626 year: 2011 article-title: The chronic bronchitic phenotype of COPD: an analysis of the COPDGene study publication-title: Chest doi: 10.1378/chest.10-2948 – volume: 34 start-page: 831 year: 2011 article-title: Ventilation-based segmentation of the lungs using hyperpolarized (3)He MRI publication-title: J Magn Reson Imaging doi: 10.1002/jmri.22738 – volume: 8 year: 2019 article-title: Role of medical and molecular imaging in COPD publication-title: Clin Transl Med doi: 10.1186/s40169-019-0231-z – volume: 2 year: 2014 article-title: Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers publication-title: Physiol Rep doi: 10.14814/phy2.12068 – volume: 15 year: 2014 article-title: The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes publication-title: Respir Res doi: 10.1186/s12931-014-0127-9 – volume: 2 year: 2014 ident: 2024092104051364000_76.2.178.5 article-title: Hyperpolarized 3He and 129Xe magnetic resonance imaging apparent diffusion coefficients: physiological relevance in older never- and ex-smokers publication-title: Physiol Rep doi: 10.14814/phy2.12068 – ident: 2024092104051364000_76.2.178.10 doi: 10.1148/radiol.2382042196 – ident: 2024092104051364000_76.2.178.2 doi: 10.1186/s12931-014-0127-9 – volume: 8 year: 2019 ident: 2024092104051364000_76.2.178.7 article-title: Role of medical and molecular imaging in COPD publication-title: Clin Transl Med doi: 10.1186/s40169-019-0231-z – ident: 2024092104051364000_76.2.178.3 doi: 10.1016/j.bbrc.2011.09.006 – volume: 26 start-page: 326 year: 2019 ident: 2024092104051364000_76.2.178.6 article-title: Probing changes in lung physiology in COPD using CT, perfusion MRI, and hyperpolarized xenon-129 MRI publication-title: Acad Radiol doi: 10.1016/j.acra.2018.05.025 – ident: 2024092104051364000_76.2.178.9 doi: 10.1378/chest.10-2948 – ident: 2024092104051364000_76.2.178.4 doi: 10.1002/nbm.3179 – ident: 2024092104051364000_76.2.178.8 doi: 10.1002/jmri.22738 – ident: 2024092104051364000_76.2.178.1 doi: 10.1164/rccm.201311-2006PP |
| SSID | ssj0008117 |
| Score | 2.465874 |
| Snippet | To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic... |
| SourceID | pubmedcentral proquest pubmed crossref bmj |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 178 |
| SubjectTerms | Aged Blood Brief Communication Carbon monoxide Case-Control Studies Chronic obstructive pulmonary disease COPD pathology COPD ÀÜ mechanisms Coronary vessels Defects Disease Emphysema Female Humans imaging/CT MRI etc lung physiology Magnetic Resonance Imaging - methods Male Middle Aged Pathophysiology Pulmonary arteries Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Gas Exchange Regions respiratory measurement Tomography, X-Ray Computed Ventilation Xenon Isotopes |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9swEBdrC2Mvpeu-3HZDg71soNW2ZCt-KiVt6QbZxlgh7MVI8nlJSe20SUv-_N7ZirNssO5ZJ2Sf7nT3032IsXeldonpRaUw6NsLpZwVFg9LASUau14IqWnqKwZf0vML9XmYDP2F28ynVS7PxOagLmpHd-SHMdVEZiqKo6PptaBXoyi66p_Q2GBbTesylGc97ABXSEWUy6y5FDXJV_BEMj2cj5DDi8tqgmKCACpGoEBF7xv26nLdQv3ldv6ZPfmbOTrbYdvej-TH7cY_ZY-g2mWPBz5S_oz97K86MTfM53XJf5kZh0Vb68vHFe9__XbC6SaWU1i-ntxBIaYjtGt8hPD0ZkqwdzyDgi-gqiuBRpsPvn96zi7OTn_0z4V_R0FY9K7mQidRCtJZCUZrh4AjBAWlQWyYZSWgytq4l9gMkReSSIidiUFmUIYalHWIZ16wTVwFXjFeaBebpOhlpQuVlsomYQRFYVJAzzGTLmAfkIO514NZ3kAMmeYdu3Nid96yO2DviXjattV4iFYtNyV3vns5PaIxeWjax27af65zsNzx1V-sZC9gb7th1EMKrpgK6luiSTRFmZUO2MtWQLoVpYyo_jgLmF4TnY6Aenyvj1TjUdPrGxdO0KXc-_dn7bMnMeXaNNnkB2xzfnMLr9FZmts3jUbcAxSeEiY priority: 102 providerName: ProQuest |
| Title | Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI |
| URI | https://thorax.bmj.com/content/76/2/178.full https://www.ncbi.nlm.nih.gov/pubmed/33139449 https://www.proquest.com/docview/2478194121 https://www.proquest.com/docview/2457304647 https://pubmed.ncbi.nlm.nih.gov/PMC7815893 |
| Volume | 76 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwED-tmzTtZeJ7gVEZiReQzBLHiZvHUTYGUsY0bajwEtnOZe1U0mrtUP98zkmarQM0eIqUnGPlzuf7Xe7DAK8LZSPdCwquCdtzKa3hhjZLjgUZu56Psa7qK9Lj-Ohcfh5EgzXY-3MEPwjjvfmQeLG4LMckUHJ1BEF6ITuw4fqyVEcWfDtrt15XNblMk4tJdZqSnb--Zgs2wzBwtaGEMDvmx-WqdfoNct7NnLxlig4fwHaDIdl-LfSHsIblI9hMmyj5Y_jev-nCXDGeTQp2oWcMF3WdLxuVrP_l5ANzf2GZC8lPxj8x59Mh2TQ2JNf0aupc3tEMc7bAclJyMtgsPf30BM4PD876R7w5Q4EbQlZzrqIgxtCaELVSlpwNHyUWmvzCJCmQ1NWIXmQS8rqIJERhtcAwwcJXKI0lX-YprNMsuAMsV1boKO8lhfUlMd9EfoB5rmMk1JiE1oO3xMGs0YFZVrkXYZy1nM8c57Oa8x68ccTTuqXGfbRyKZTMNp3L3QEa4_uGvWuH_eM8u0uJ33yFcLW4iQxE4MGr9jHpoAus6BIn144mUi7CLJUHz-oF0s64XF8eqJWl0xK4_t6rT8rRsOrzTRNHBCef_werXsCWcEk3VVr5LqzPr67xJaGmuelCRw1Ut9KXLmzs99P0K13fHxyfnNLdj4PgF_F-FKk |
| linkProvider | BMJ Publishing Group Ltd |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VVAIuiDeGAosEB5CW2uu1Nz4gBGmrhDahqlqp6sWs12OSKjihSSH8KX4jM36FgES59OxZrT2vnfHON8PY80zbwLS9TBiM7YVSNhEJOksBGR52bRdCU-Ar-oOwe6Q-HAfHa-xnjYWhssraJxaOOp1Y-ke-KQkTGSlPem-nXwVNjaLb1XqERqkWu_DjO6Zssze9LZTvCyl3tg87XVFNFRAJxhpzoQMvBN8mPhitLYbfLijIDGZKUZQBKnAi20ESYR6CJD5IayT4EWSuBpVYTVMi0OWvK0K0ttj6--3B_kHj-wm2WdfphWi7FWbI88PN-RBlujjNx6iYmLJJTE0IZn8l-XK6eib-Fej-Wa_52wG4c5PdqCJX_q5UtVtsDfLb7Gq_upu_w046y97Phbj5JOOfzYzDokQX81HOOx_3tzj9--VUCDAZf4NUTId4kvIhJsRnU0q0RzNI-QLySS4wTOD9g95ddnQpPL7HWrgLPGA81VaaIG1HmXWV9lUSuB6kqQkBY9XItw57hRyMK8ubxUVS44dxw-6Y2B2X7HbYSyKelo08LqJVtVBiW_VLp7Ed44uWvW6W_ec-G7XEl1-x1HaHPWseo-XTdY7JYXJONIGme22lHXa_VJBmR9_3CPEcOUyvqE5DQF3FV5_ko2HRXRw3DjCIffjv13rKrnUP-3vxXm-w-4hdl1TpU9Syb7DW_OwcHmOoNk-eVPbB2afLNslfnElQ2Q |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbGkCZeEHcCA4wEDyCZJrYTNw8IoZZqZXRMiEkVL5ntnNBOJSlrB-Wv8es4zq0UJMbLnnMsJ-fm78TnQsiTTNlQd4OMacT2TEprmEFnySDDw67rQ6TL-orRQbR3JN-Ow_EW-dnUwri0ysYnlo46Laz7R97hriYylgEPOlmdFnHYH7yaf2VugpS7aW3GaVQqsg8_vmP4tng57KOsn3I-ePOxt8fqCQPMIO5YMhUGEQhrBGilLEJxHyRkGqOmOM4AldnwbmhijEmQRAC3moOIIfMVSGOVmxiB7v-yEoiq0JbUuA32fFfA2WTsRWjFdfVQIKLOcoLSXZ3kM1RRDN44Bimu4P6S-XKyeTr-BXn_zNz87SgcXCNXawxLX1dKd51sQX6D7IzqW_qb5FNv3QW6FDwtMvpZLyisqjpjOs1p7_1hn7q_wNSlBBSzb5Cy-QTPVDrB0Ph07kLu6QJSuoK8yBkCBjr6MLxFji6Ew7fJNu4CdwlNleU6TLtxZn2phDShH0Ca6ggQtcbCeuQ5cjCpbXCRlOGNiJKW3Yljd1Kx2yPPHPG8aulxHq1shJLYunO6G-AxO2_Zi3bZf-6z20h8_RVrvffI4_Yx-gB3saNzKM4cTajcDbdUHrlTKUi7oxCBq32OPaI2VKclcP3FN5_k00nZZxw3DhHO3vv3az0iO2iIybvhwf59coW7lJ8yqX2XbC9Pz-ABYraleVgaByXHF22NvwBu8VOg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Characterisation+of+gas+exchange+in+COPD+with+dissolved-phase+hyperpolarised+xenon-129+MRI&rft.jtitle=Thorax&rft.au=Myc%2C+Lukasz&rft.au=Qing%2C+Kun&rft.au=He%2C+Mu&rft.au=Tustison%2C+Nicholas&rft.date=2021-02-01&rft.issn=1468-3296&rft.eissn=1468-3296&rft.volume=76&rft.issue=2&rft.spage=178&rft_id=info:doi/10.1136%2Fthoraxjnl-2020-214924&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0040-6376&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0040-6376&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0040-6376&client=summon |