Characterisation of gas exchange in COPD with dissolved-phase hyperpolarised xenon-129 MRI

• Published in: Thorax Vol. 76; no. 2; pp. 178 - 181
• Main Authors: Myc, Lukasz, Qing, Kun, He, Mu, Tustison, Nicholas, Lin, Zixuan, Manichaikul, Ani W, Patrie, James, Cassani, Joanne, Nunoo-Asare, Roselove N, Huang, Yong, Obaida, Zaid, Tafti, Sina, Ropp, Alan M, Miller, Grady Wilson, Mata, Jaime, Altes, Talissa, Mugler, John, Shim, Y Michael
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Thoracic Society 01.02.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Aged; Blood; Brief Communication; Carbon monoxide; Case-Control Studies; Chronic obstructive pulmonary disease; COPD pathology; COPD ÀÜ mechanisms; Coronary vessels; Defects; Disease; Emphysema; Female; Humans; imaging/CT MRI etc; lung physiology; Magnetic Resonance Imaging - methods; Male; Middle Aged; Pathophysiology; Pulmonary arteries; Pulmonary Disease, Chronic Obstructive - diagnostic imaging; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Gas Exchange; Regions; respiratory measurement; Tomography, X-Ray Computed; Ventilation; Xenon Isotopes; respiratory measurement; COPD ÀÜ mechanisms; lung physiology; imaging/CT MRI etc; COPD pathology; emphysema
• ISSN: 0040-6376; 1468-3296; 1468-3296
• DOI: 10.1136/thoraxjnl-2020-214924

To investigate whether hyperpolarised xenon-129 MRI (HXeMRI) enables regional and physiological resolution of diffusing capacity limitations in chronic obstructive pulmonary disease (COPD), we evaluated 34 COPD subjects and 11 healthy volunteers. We report significant correlations between airflow abnormality quantified by HXeMRI and per cent predicted forced expiratory volume in 1 s; HXeMRI gas transfer capacity to red blood cells and carbon monoxide diffusion capacity (%DLCO); and HXeMRI gas transfer capacity to interstitium and per cent emphysema quantified by multidetector chest CT. We further demonstrate the capability of HXeMRI to distinguish varying pathology underlying COPD in subjects with low %DLCO and minimal emphysema.