Acute effects of 40% oxygen supplementation in adults with cyanotic congenital heart disease

• Published in: Heart (British Cardiac Society) Vol. 90; no. 9; pp. 1073 - 1074
• Main Authors: Walker, F, Mullen, M J, Woods, S J, Webb, G D
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Cardiovascular Society 01.09.2004; BMJ; BMJ Publishing Group LTD; Copyright 2004 by Heart
• Subjects: Adult; Aged; Analysis of Variance; Biological and medical sciences; Cardiology. Vascular system; Cardiopathies: etiologic forms (general aspects and miscellaneous); Cardiovascular disease; CCHD; Congenital diseases; congenital heart disease; cyanosis; Cyanosis - therapy; cyanotic congenital heart disease; Heart; Heart Defects, Congenital - complications; Heart rate; Humans; Medical sciences; Middle Aged; Mortality; Oxygen; Oxygen - administration & dosage; Oxygen therapy; Physiology; Pulmonary arteries; Pulmonary hypertension; Quality of life; Respiratory therapy; SAOS; Scientific Letters; systemic arterial oxygen saturation; Variance analysis; Human; Oxygen; Acute; Cardiovascular disease; Adult; Circulatory system; Supplementation; Cardiology; Congenital cardiopathy; Cyanotic heart disease; Phlebology
• ISSN: 1355-6037; 1468-201X
• DOI: 10.1136/hrt.2002.000299

Oxygen administration was associated with a significant decrease in heart rate (room air 78 (15.4) bpm, 40% oxygen 73 (11.4) bpm, and 95% oxygen 71 (10.9) bpm, p < 0.001), but no significant change in systemic systolic blood pressure (room air 115 (14) mm Hg, 40% oxygen 112 (15) mm Hg, and 95% oxygen 114 (17) mm Hg, p = not significant). Previously reported invasive experiments with 95-100% supplemental oxygen, in similar patient cohorts, confirmed that pulmonary vascular resistance decreased and pulmonary blood flow increased with little or no effect on right to left shunting. 3- 5 This high concentration of supplemental oxygen is not suitable for long term therapy, however, because it is associated with lung toxicity.