Prognostic impact of VEGF, CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB–IIA non-small cell lung cancer
Aims: To evaluate the prognostic impact of tumour angiogenesis assessed by vascular endothelial growth factor (VEGF), microvessel density (MVD), and tumour vessel invasion in patients who had undergone radical resection for stage IB–IIA non-small cell lung cancer (NSCLC). Methods: Fifty one patients...
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Published in | Journal of clinical pathology Vol. 57; no. 6; pp. 591 - 597 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd and Association of Clinical Pathologists
01.06.2004
BMJ BMJ Publishing Group LTD Copyright 2004 Journal of Clinical Pathology |
Subjects | |
Online Access | Get full text |
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Summary: | Aims: To evaluate the prognostic impact of tumour angiogenesis assessed by vascular endothelial growth factor (VEGF), microvessel density (MVD), and tumour vessel invasion in patients who had undergone radical resection for stage IB–IIA non-small cell lung cancer (NSCLC). Methods: Fifty one patients (42 men, nine women; mean age, 62.3 years; SD, 6.9) undergoing complete surgical resection (35 lobectomy, 16 pneumonectomy) of pathological stage IB (n = 43) and IIA (n = 8) NSCLC were evaluated retrospectively. No patient underwent postoperative chemotherapy or neoadjuvant treatment. Tumour specimens were stained for VEGF and specific MVD markers: CD31, CD34, and CD105. Results: VEGF expression significantly correlated with high CD105 expression (p < 0.0001) and tumour vessel invasion (p = 0.04). Univariate analysis showed that those patients with VEGF overexpression (p = 0.0029), high MVD by CD34 (p = 0.0081), high MVD by CD105 (p = 0.0261), and tumour vessel invasion (p = 0.0245) have a shorter overall survival. Furthermore, multivariate Cox regression analysis showed that MVD by CD34 (p = 0.007), tumour vessel invasion (p = 0.024), and VEGF expression (p = 0.042) were significant predictive factors for overall survival. Finally, the presence of both risk factors, tumour vessel invasion and MVD by CD34, was highly predictive of poor outcome (odds ratio, 3.4; 95% confidence interval, 1.7 to 6.5; p = 0.0002). Conclusions: High MVD by CD34 and tumour vessel invasion are more closely related to poor survival than the other neoangiogenetic factors in stage IB–IIA NSCLC. This may be because these factors are more closely related to the metastatic process. |
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Bibliography: | ark:/67375/NVC-KSD62R21-R href:jclinpath-57-591.pdf Correspondence to: Professor T C Mineo Department of Thoracic Surgery, Policlinic Tor Vergata University, 00133 Rome, Italy; mineo@med.uniroma2.it and Dr G Tonini Medical Oncology, Campus Bio-Medico University, Rome. Via Emilio Longoni, 69, 00155, Rome, Italy; g.tonini@unicampus.it istex:B01050DB67660D2C220E7AC4345B2208FFFF74BB PMID:15166262 local:0570591 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to: Professor T C Mineo Department of Thoracic Surgery, Policlinic Tor Vergata University, 00133 Rome, Italy; mineo@med.uniroma2.it and Dr G Tonini Medical Oncology, Campus Bio-Medico University, Rome. Via Emilio Longoni, 69, 00155, Rome, Italy; g.tonini@unicampus.it |
ISSN: | 0021-9746 1472-4146 |
DOI: | 10.1136/jcp.2003.013508 |