An evidence based approach to individualising treatment

• Published in: BMJ Vol. 311; no. 7016; pp. 1356 - 1359
• Main Authors: Glasziou, Paul P, Irwig, Les M
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 18.11.1995; British Medical Association; BMJ Publishing Group LTD; BMJ Group
• Subjects: Anticoagulants; Assumption of risk; Atrial fibrillation; Clinical trials; Control groups; Decision Support Techniques; Disease; Education & Debate; Experimentation; Health risk assessment; Humans; Intracranial hemorrhages; Military benefits; Mortality; Outcome Assessment (Health Care); Predisposing factors; Randomized Controlled Trials as Topic; Risk Assessment; Risk factors; Stroke; Strokes
• DOI: 10.1136/bmj.311.7016.1356
• ISSN: 0959-8138

To which groups of patients can the results of clinical trials be applied? This question is often inappropriately answered by reference to the trial entry criteria. Instead, the benefit and harm (adverse events, discomfort of treatment, etc) of treatment could be assessed separately for individual patients. Patients at greatest risk of a disease will have the greatest net benefit as benefit to patients usually increases with risk while harm remains comparatively fixed. To assess net benefit, the relative risks should come from (a meta-analysis of) randomised trials; the risk in individual patients should come from multivariate risk equations derived from cohort studies. However, before making firm conclusions, the assumptions of fixed adverse effects and constant reduction in relative risk need to be checked.