An evidence based approach to individualising treatment
To which groups of patients can the results of clinical trials be applied? This question is often inappropriately answered by reference to the trial entry criteria. Instead, the benefit and harm (adverse events, discomfort of treatment, etc) of treatment could be assessed separately for individual p...
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Published in | BMJ Vol. 311; no. 7016; pp. 1356 - 1359 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
British Medical Journal Publishing Group
18.11.1995
British Medical Association BMJ Publishing Group LTD BMJ Group |
Subjects | |
Online Access | Get full text |
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Summary: | To which groups of patients can the results of clinical trials be applied? This question is often inappropriately answered by reference to the trial entry criteria. Instead, the benefit and harm (adverse events, discomfort of treatment, etc) of treatment could be assessed separately for individual patients. Patients at greatest risk of a disease will have the greatest net benefit as benefit to patients usually increases with risk while harm remains comparatively fixed. To assess net benefit, the relative risks should come from (a meta-analysis of) randomised trials; the risk in individual patients should come from multivariate risk equations derived from cohort studies. However, before making firm conclusions, the assumptions of fixed adverse effects and constant reduction in relative risk need to be checked. |
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Bibliography: | PMID:7496291 ark:/67375/NVC-ZFSCCZFX-P local:bmj;311/7016/1356 href:bmj-311-1356.pdf Correspondence to: Dr Glasziou. istex:73D63058194EEE5D104F17FA3370A02E4BC80094 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0959-8138 1468-5833 1756-1833 |
DOI: | 10.1136/bmj.311.7016.1356 |