Functions of cyclins and CDKs in mammalian gametogenesis

Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of our understanding of their functions has been obtained from studies in single-cell organisms and mitotically proliferating cultured cells. In mammals, there are more than 20 cyclins and 20 CDKs. Although geneti...

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Published inBiology of reproduction Vol. 101; no. 3; pp. 591 - 601
Main Authors Chotiner, Jessica Y, Wolgemuth, Debra J, Wang, P. Jeremy
Format Journal Article
LanguageEnglish
Published United States Society for the Study of Reproduction 01.09.2019
Oxford University Press
Subjects
Ablation
Biological research
CDK
Cell cycle
Cell division
cyclin
cyclin-dependent kinase
Cyclin-dependent kinases
Cyclins
DNA
DNA replication
Embryonic development
Gametogenesis
Genetic research
Mammals
meiosis
oogenesis
Reviews
spermatogenesis
Yeast
United States
cyclin
meiosis
cell cycle
gametogenesis
spermatogenesis
CDK
cyclin-dependent kinase
oogenesis
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Summary:Cyclins and cyclin-dependent kinases (CDKs) are key regulators of the cell cycle. Most of our understanding of their functions has been obtained from studies in single-cell organisms and mitotically proliferating cultured cells. In mammals, there are more than 20 cyclins and 20 CDKs. Although genetic ablation studies in mice have shown that most of these factors are dispensable for viability and fertility, uncovering their functional redundancy, CCNA2, CCNB1, and CDK1 are essential for embryonic development. Cyclin/CDK complexes are known to regulate both mitotic and meiotic cell cycles. While some mechanisms are common to both types of cell divisions, meiosis has unique characteristics and requirements. During meiosis, DNA replication is followed by two successive rounds of cell division. In addition, mammalian germ cells experience a prolonged prophase I in males or a long period of arrest in prophase I in females. Therefore, cyclins and CDKs may have functions in meiosis distinct from their mitotic functions and indeed, meiosis-specific cyclins, CCNA1 and CCNB3, have been identified. Here, we describe recent advances in the field of cyclins and CDKs with a focus on meiosis and early embryogenesis. Summary Sentence A comprehensive review on genetic studies of cyclins and CDKs in mouse germ cell development.
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ISSN:0006-3363
1529-7268
DOI:10.1093/biolre/ioz070