The effect of nilvadipine on bloodflow in the dorsal pedis artery in type 2 diabetic patients--a study using duplex Doppler ultrasonography

• Published in: Postgraduate medical journal Vol. 71; no. 840; pp. 613 - 616
• Main Authors: Sone, H., Okuda, Y., Mizutani, M., Kawakami, Y., Bannai, C., Yamashita, K.
• Format: Journal Article
• Language: English
• Published: London The Fellowship of Postgraduate Medicine 01.10.1995; BMJ; Oxford University Press; BMJ Group
• Subjects: Arteries - diagnostic imaging; Arteries - physiopathology; Biological and medical sciences; Blood Flow Velocity - drug effects; Calcium Channel Blockers - pharmacology; Cardiovascular system; Diabetes Mellitus, Type 2 - diagnostic imaging; Diabetes Mellitus, Type 2 - physiopathology; Female; Foot - blood supply; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Nifedipine - analogs & derivatives; Nifedipine - pharmacology; Ultrasonic investigative techniques; Ultrasonography, Doppler, Duplex - drug effects; Endocrinopathy; Sonography; Human; Hypertension; Diabetes mellitus; Calcium antagonist; Cardiovascular disease; Exploration; Duplex ultrasonography; Dihydropyridine derivative; Blood flow; Concomitant disease; Chemotherapy; Treatment; Antihypertensive agent; Hemodynamics; Dorsal artery of the foot
• ISSN: 0032-5473; 1469-0756
• DOI: 10.1136/pgmj.71.840.613

The effects of nilvadipine on the peripheral circulation in the lower extremities using a duplex system of two-dimensional colour and pulse Doppler ultrasonography were studied in 32 patients with type 2 diabetes mellitus and mild essential hypertension. The patients (19 men and 13 women) were randomly divided into treatment and control groups. The anatomical cross-sectional area and blood flow index of the dorsal pedis artery were determined by colour and pulse Doppler ultrasonography before and 60 min after administration of 4 mg nilvadipine or placebo. Pulse rate and blood pressure were measured simultaneously. There were no significant changes in pulse rate or blood pressure after administration of either drug. Both cross-sectional areas (from 4.3 +/- 0.4 to 5.2 +/- 0.5 mm2, p < 0.05) and blood flow index (from 40.3 +/- 4.3 to 58.8 +/- 9.0, p < 0.05) were significantly increased in the treatment group, whereas there were no significant changes in either measurement in the control group. The findings showed that a single administration of nilvadipine increases blood flow in the dorsal pedis arteries of diabetic patients.