Occupational triphenyltin acetate poisoning: a case report

• Published in: British Journal of Industrial Medicine Vol. 48; no. 2; pp. 136 - 139
• Main Authors: Colosio, C, Tomasini, M, Cairoli, S, Foà, V, Minoia, C, Marinovich, M, Galli, C L
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.02.1991; British Medical Association; BMJ; BMJ Publishing Group LTD
• Subjects: Accidents; Acetates; Actins; Adult; Biological and medical sciences; Blood; Dermatitis, Occupational - chemically induced; Dermatitis, Occupational - pathology; Dermatitis, Occupational - urine; Electroencephalography - drug effects; Excretion; Fungicides, Industrial - poisoning; Humans; Liver; Liver - drug effects; Male; Medical sciences; Neutrophils; Neutrophils - drug effects; Organotin Compounds - poisoning; Pesticides, fertilizers and other agrochemicals toxicology; Poisoning; Skin - pathology; Skin Absorption; Tin; Tin - urine; Toxicology; Urine; Urticaria - chemically induced; Urticaria - pathology; Urticaria - urine; Human; Allergy; Toxicity; Urticaria; Acute; Pesticides; Occupational exposure; Biological monitoring; Heavy metal; Percutaneous route; Case study; Toxicokinetics; Occupational accident; Neutrophile; Skin; Tin Organic compounds; Topical administration
• ISSN: 0007-1072; 1351-0711; 1470-7926
• DOI: 10.1136/oem.48.2.136

A case of triphenyltin acetate (TPTA) poisoning is described. The patient, who had been exposed mainly to cutaneous absorption, showed acute stages of an urticarial eruption, signs of hepatic injury, slight glucose intolerance, and electroencephalographic abnormalities. Concomitant with the highest concentrations of tin in plasma and the peak of tin excretion in urine, neutrophils did not show the normal increase in actin polymerisation after stimulation with a chemotactic peptide (100 nM fMLP). The peak of urinary excretion of tin occurred between the fifth and the sixth day after poisoning; subsequently, the rate of excretion became slow, suggesting biphasic kinetics with the possibility of a cumulative trend.