Cogan's syndrome: an oculo-audiovestibular disease

• Published in: Postgraduate Medical Journal Vol. 75; no. 883; pp. 262 - 264
• Main Authors: Berrocal, J R García, Vargas, J A, Vaquero, M, y Cajal, S Ramón, Ramírez-Camacho, R A
• Format: Journal Article Book Review
• Language: English
• Published: London The Fellowship of Postgraduate Medicine 01.05.1999; BMJ; Oxford University Press; BMJ Group
• Subjects: Adrenal Cortex Hormones - therapeutic use; Adult; autoimmune disease; Autoimmune Diseases - diagnosis; Autoimmune Diseases - drug therapy; Biological and medical sciences; Cogan's syndrome; Deafness - diagnosis; Deafness - drug therapy; Diseases of cornea, anterior segment and sclera; Eye Diseases - diagnosis; Eye Diseases - drug therapy; hearing loss; Humans; Magnetic Resonance Imaging; Male; Medical sciences; Ophthalmology; Review; Syndrome; Human; Corticosteroid; Pathogenesis; Cardiovascular disease; Keratopathy; Review; Aortic regurgitation; Differential diagnostic; Symptomatology; Eye disease; Chemotherapy; Treatment; Cardiac valvular disease; Surgery; Cogan syndrome; ENT disease; Complication; Evolution; Diagnosis; Aortic valve
• ISSN: 0032-5473; 1469-0756
• DOI: 10.1136/pgmj.75.883.262

Typical Cogan's syndrome is a rare disease of young adults consisting of flares of interstitial keratitis and sudden onset of Ménière-like attacks (nausea, vomiting, tinnitus, vertigo and hearing loss). Life-threatening aortic insufficiency develops in 10% of reported cases. Atypical Cogan's syndrome (audiovestibular dysfunction with other types of inflammatory eye disease) is associated with vasculitis in 20% of cases and has a less favourable prognosis than typical Cogan's syndrome.