Acute headache as a presenting symptom of tacrolimus encephalopathy
A 24 year old woman presented with a sudden excruciating headache mimicking an acute vascular event. She had undergone a lung transplantation because of cystic fibrosis and was receiving maintenance treatment with tacrolimus and prednisone. Ancillary investigation excluded vascular causes. Magnetic...
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Published in | Journal of neurology, neurosurgery and psychiatry Vol. 74; no. 8; pp. 1126 - 1127 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
London
BMJ Publishing Group Ltd
01.08.2003
BMJ BMJ Publishing Group LTD BMJ Group |
Subjects | |
Online Access | Get full text |
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Summary: | A 24 year old woman presented with a sudden excruciating headache mimicking an acute vascular event. She had undergone a lung transplantation because of cystic fibrosis and was receiving maintenance treatment with tacrolimus and prednisone. Ancillary investigation excluded vascular causes. Magnetic resonance imaging demonstrated hyperintense lesions in the infratentorial and parieto-occipital regions consistent with posterior leucencephalopathy syndrome. Both her clinical condition improved and the lesions disappeared completely after withdrawal of tacrolimus, suggesting that her condition could be explained by a tacrolimus encephalopathy. |
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Bibliography: | istex:85EE875088B71ACE8EA741FE6765AF96381B1459 href:jnnp-74-1126.pdf PMID:12876250 ark:/67375/NVC-7JXLPZZH-R local:0741126 Correspondence to: Dr F-E de Leeuw, University Medical Centre St Radboud, Nijmegen, PO Box 9101, 6500IIB Nijmegen, The Netherlands; hdeleeuw@neuro.umcn.nl |
ISSN: | 0022-3050 1468-330X |
DOI: | 10.1136/jnnp.74.8.1126 |