Cardiovascular magnetic resonance of pulmonary artery growth and ventricular function after Norwood procedure with Sano modification

• Published in: Journal of cardiovascular magnetic resonance Vol. 10; no. 1; p. 34
• Main Authors: Lim, D Scott, Peeler, Benjamin B, Matherne, G Paul, Kramer, Christopher M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.07.2008; BioMed Central; Elsevier
• Subjects: Cardiovascular Surgical Procedures - adverse effects; Cardiovascular Surgical Procedures - methods; Care and treatment; Cohort Studies; Constriction, Pathologic - diagnosis; Constriction, Pathologic - physiopathology; Contrast Media - administration & dosage; Diagnosis; Follow-Up Studies; Humans; Hypoplastic left heart syndrome; Hypoplastic Left Heart Syndrome - physiopathology; Hypoplastic Left Heart Syndrome - surgery; Image Enhancement - methods; Image Processing, Computer-Assisted; Infant; Infant, Newborn; Magnetic Resonance Angiography - methods; Magnetic resonance imaging; Methods; Palliative Care - methods; Physiological aspects; Postoperative Complications - diagnosis; Postoperative Complications - physiopathology; Pulmonary Artery - growth & development; Pulmonary Artery - pathology; Pulmonary Artery - physiopathology; Risk factors; Survival Rate; Ventricular Function; United States
• ISSN: 1097-6647; 1532-429X; 1532-429X
• DOI: 10.1186/1532-429X-10-34

For hypoplastic left heart syndrome (HLHS), there have been concerns regarding pulmonary artery growth and ventricular dysfunction after first stage surgery consisting of the Norwood procedure modified with a right ventricle-to-pulmonary artery conduit. We report our experience using cardiovascular magnetic resonance (CMR) to determine and follow pulmonary arterial growth and ventricular function in this cohort. Following first stage palliation, serial CMR was performed at 1 and 10 weeks post-operatively, followed by cardiac catheterization at 4-6 months. Thirty-four of 47 consecutive patients with HLHS (or its variations) underwent first stage palliation. Serial CMR was performed in 20 patients. Between studies, ejection fraction decreased (58 +/- 9% vs. 50 +/- 5%, p < 0.05). Pulmonary artery growth occurred on the left (6 +/- 1 mm vs. 4 +/- 1 mm at baseline, p < 0.05) but not significantly in the right. This trend continued to cardiac catheterization 4-6 months post surgery, with the left pulmonary artery of greater size than the right (8.8 +/- 2.2 mm vs. 6.7 +/- 1.9 mm, p < 0.05). By CMR, 5 had pulmonary artery stenoses initially, and at 2 months, 9 had stenoses. Three of the 9 underwent percutaneous intervention prior to the second stage procedure. In this cohort, reasonable growth of pulmonary arteries occurred following first stage palliation with this modification, although that growth was preferential to the left. Serial studies demonstrate worsening of ventricular function for the cohort. CMR was instrumental for detecting pulmonary artery stenosis and right ventricular dysfunction.