Protein engineering: a new frontier for biological therapeutics

Protein engineering holds the potential to transform the metabolic drug landscape through the development of smart, stimulusresponsive drug systems. Protein therapeutics are a rapidly expanding segment of Food and Drug Administration approved drugs that will improve clinical outcomes over the long r...

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Bibliographic Details
Published inCurrent drug metabolism Vol. 15; no. 7; p. 743
Main Authors Tobin, Peter H, Richards, David H, Callender, Randolph A, Wilson, Corey J
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2014
Subjects
Animals
Antidotes - therapeutic use
Biological Products - therapeutic use
Humans
Prodrugs - therapeutic use
Protein Engineering
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Summary:Protein engineering holds the potential to transform the metabolic drug landscape through the development of smart, stimulusresponsive drug systems. Protein therapeutics are a rapidly expanding segment of Food and Drug Administration approved drugs that will improve clinical outcomes over the long run. Engineering of protein therapeutics is still in its infancy, but recent general advances in protein engineering capabilities are being leveraged to yield improved control over both pharmacokinetics and pharmacodynamics. Stimulus- responsive protein therapeutics are drugs which have been designed to be metabolized under targeted conditions. Protein engineering is being utilized to develop tailored smart therapeutics with biochemical logic. This review focuses on applications of targeted drug neutralization, stimulus-responsive engineered protein prodrugs, and emerging multicomponent smart drug systems (e.g., antibody-drug conjugates, responsive engineered zymogens, prospective biochemical logic smart drug systems, drug buffers, and network medicine applications).
ISSN:1875-5453
DOI:10.2174/1389200216666141208151524