Poor clinical outcome despite successful basilar occlusion recanalization in the early time window: incidence and predictors

• Published in: Journal of neurointerventional surgery Vol. 15; no. 5; pp. 415 - 421
• Main Authors: Pop, Raoul, Finitsis, Stephanos Nikolaos, Arquizan, Caroline, Elhorany, Mahmoud, Naggara, Olivier, Darcourt, Jean, Clarençon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Blanc, Raphaël, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Caroff, Jildaz, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Rouchaud, Aymeric, Macian, Francisco, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Albucher, Jean François, Le Bras, Anthony, Evain, Sarah, Wolff, Valerie, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Papagiannaki, Chrysanthi, Gory, Benjamin
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.05.2023; BMJ Publishing Group LTD; BMJ Journals
• Subjects: Arterial Occlusive Diseases - etiology; Basilar Artery - diagnostic imaging; Clinical outcomes; Cognitive science; Endovascular Procedures - methods; Humans; Incidence; Ischemic stroke; Mortality; Neuroscience; Patients; Prospective Studies; Retrospective Studies; Stroke; Stroke - therapy; Thrombectomy; Thrombectomy - methods; Treatment Outcome; Veins & arteries; France; Stroke; Thrombectomy
• ISSN: 1759-8478; 1759-8486
• DOI: 10.1136/neurintsurg-2022-018769

BackgroundEndovascular treatment (EVT) for basilar artery occlusions (BAO) is associated with a higher rate of futile recanalization compared with anterior circulation procedures. We aimed to identify the incidence and predictors of poor clinical outcome despite successful reperfusion in current clinical practice.MethodsWe used data from the ETIS (Endovascular Treatment in Ischemic Stroke) registry, a prospective multicenter observational registry of stroke treated with EVT in France. Patients undergoing EVT for acute BAO from January 2014 to May 2019 successfully treated within 8 hours from onset were included. Predictors of 90-day poor outcome (modified Rankin Scale (mRS) 4–6) were researched within patients with successful (modified Thrombolysis In Cerebral Infarction (mTICI 2b-3)) and excellent (mTICI 2c-3) reperfusion.ResultsAmong 242 patients treated within 8 hours, successful reperfusion was achieved in 195 (80.5%) and excellent reperfusion in 120 (49.5%). Poor outcome was observed in 107 (54.8%) and 60 (50%) patients, respectively. In patients with successful early reperfusion, age, higher initial National Institutes of Health Stroke Scale (NIHSS) score, lower posterior circulation Alberta Stroke Programme Early CT Score (pc-ASPECTS), and absence of prior intravenous thrombolysis were independent predictors of poor outcome. The only treatment factor with an independent predictive value was first-pass mTICI 2b-3 reperfusion (adjusted OR 0.13, 95% CI 0.05 to 0.37, p<0.001). In patients with excellent early reperfusion, independent predictors were age, initial NIHSS score, first-pass mTICI 2c-3 reperfusion, and hemorrhagic transformation on post-interventional imaging.ConclusionsEarly successful reperfusion with EVT occurred in 80.5% of patients, and the only treatment-related factor predictive of clinical outcome was first pass mTICI 2b-3 reperfusion. Further research is warranted to identify the optimal techniques and devices associated with first pass reperfusion in the posterior circulation.