Pseudoangiosarcomatous carcinoma of the genitourinary tract

• Published in: Journal of clinical pathology Vol. 48; no. 11; pp. 1059 - 1061
• Main Authors: Pitt, M A, Morphopoulos, G, Wells, S, Bisset, D L
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.11.1995; BMJ; BMJ Publishing Group LTD
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma - pathology; Diagnosis, Differential; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Hemangiosarcoma - pathology; Humans; Medical sciences; Middle Aged; Tumors; Urinary Bladder Neoplasms - pathology; Vulvar Neoplasms - pathology; Human; Immunohistochemistry; Urinary system disease; Carcinoma; Sarcoma; Vulva; Malignant tumor; Angiosarcoma; Differential diagnostic; Female genital diseases; Case study; Pathology; Urinary bladder; Vulvar diseases; Bladder disease
• ISSN: 0021-9746; 1472-4146
• DOI: 10.1136/jcp.48.11.1059

Two cases of pseudoangiosarcomatous carcinoma of the genitourinary tract, arising in the vulva in one and the bladder in the other, are presented. In case 1, an 84 year old woman, the vulvectomy specimen contained an irregular ulcerated tumour, infiltrating the left labia and extending into the clitoris. In case 2, a 59 year old woman, the excised bladder showed diffuse thickening of its wall by infiltrating haemorrhagic tumour. Both tumours showed focal keratinisation. This, in association with the presence of atypical squamous epithelium, immunohistochemistry and ultrastructural analysis, led to a diagnosis of pseudosarcomatous carcinoma in both cases. Pseudoangiosarcomatous carcinoma should be considered in the differential diagnosis of malignant angiomatoid tumours, particularly those that arise at sites, like the genitourinary tract, where angiosarcoma is rare.