Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine
The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two diffe...
Saved in:
Published in | Virology journal Vol. 3; no. 1; p. 91 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
02.11.2006
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The replication of porcine endogenous retrovirus (PERV) in human cell lines suggests a potential infectious risk in xenotransplantation. PERV isolated from human cells following cocultivation with porcine peripheral blood mononuclear cells is a recombinant of PERV-A and PERV-C. We describe two different recombinant PERV-AC sequences in the cellular DNA of some transmitting miniature swine. This is the first evidence of PERV-AC recombinant virus in porcine genomic DNA that may have resulted from autoinfection following exogenous viral recombination. Infectious risk in xenotransplantation will be defined by the activity of PERV loci in vivo. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1743-422X 1743-422X |
DOI: | 10.1186/1743-422X-3-91 |