Diffusion tensor imaging demonstrates deviation of fibres in normal appearing white matter adjacent to a brain tumour

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 68; no. 4; pp. 501 - 503
• Main Authors: Wieshmann, U C, Symms, M R, Parker, G J M, Clark, C A, Lemieux, L, Barker, G J, Shorvon, S D
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.04.2000; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Anisotropy; Biological and medical sciences; Brain - pathology; Brain cancer; Brain Neoplasms - pathology; Brain research; brain tumours; diffusion tensor imaging; Eigenvectors; Epilepsy; Humans; Magnetic Resonance Imaging - methods; Male; Medical sciences; Middle Aged; Multiple sclerosis; Nervous system; Neurology; Short Report; Tumors of the nervous system. Phacomatoses; Human; Intracranial; Nervous system diseases; Tensor; Exploration; Male; Nuclear magnetic resonance imaging; White matter; Cerebral disorder; Case study; Central nervous system disease; Medical imagery; Adult; Tumor; Fiber orientation; Technique; Diffusion
• ISSN: 0022-3050; 1468-330X
• DOI: 10.1136/jnnp.68.4.501

the objective was to study fibre orientation in the cerebral white matter of a patient with a brain tumour using diffusion tensor imaging (DTI).  A patient with a mild left hemiparesis and a tumour in the right frontal lobe and 20 healthy volunteers were scanned with a DTI sequence. The scans were spatially normalised and the fibre orientation in the patient compared with the fibre orientation in normal controls.  DTI disclosed a change of the orientation of fibres in the patient compared with normal controls. In the normal appearing white matter adjacent to the tumour fibres deviated from the normal superior inferior orientation in the corona radiata by about 30o. This finding was consistent with a displacement by distant mass effect rather than a destruction of fibres, in agreement with the neurological examination.  In conclusion, DTI demonstrated a deviation of fibres in normal appearing white matter adjacent to a tumour. The technique will improve understanding of the effects of structural abnormalities on fibres. This will assist the interpretation of clinical findings and functional imaging studies and guide neurosurgical interventions.