An Update on Potential Molecular Mechanisms Underlying the Actions of Snake Venom L-amino Acid Oxidases (LAAOs)

• Published in: Current medicinal chemistry Vol. 25; no. 21; p. 2520
• Main Authors: Paloschi, Mauro V, Pontes, Adriana S, Soares, Andreimar M, Zuliani, Juliana P
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2018
• Subjects: LAAO; Snake venom; inflammation; mechanism of action; apoptosis; microbicidal; aggregation; biomedical potential
• ISSN: 1875-533X
• DOI: 10.2174/0929867324666171109114125

LAAOs (EC 1.4.3.2) are found in concentrations that vary according to each species of snakes; Viperidae, Crotalidae and Elapidae contain 1-9% of this enzyme in their venoms. This review focuses on an update on molecular mechanisms, platelet activities, antimicrobial, antiprotozoal, induction of apoptosis and inflammatory potential underlying the actions of SVLAAOs. Snake venom LAAOs (SV-LAAOs) have become an interesting subject for pharmacological, structural and molecular studies. Although the mechanisms of action of these enzymes are not well understood they are a subject of a variety of studies, because LAAOs are multifunctional enzymes exhibiting a wide range of pharmacological effects, including the inhibition or induction of platelet aggregation, hemolysis and hemorrhage, in addition to the stimulation of apoptosis, the activation of leukocytes and the formation of edema. Moreover, SV-LAAOs play an important role in bactericidal, cytotoxic, anti-parasitic, anti-tumor, and antiviral activities.