The Esophageal Cancer and the PI3K/AKT/mTOR Signaling Regulatory microRNAs: a Novel Marker for Prognosis, and a Possible Target for Immunotherapy

The Phosphatidylinositol 3-kinase/AKT/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) pathway has a critical regulatory role in cell biology including translation, transcription, and autophagy. Dysregulation of this pathway is involved in the pathogenesis, development, and prognosis of esophageal canc...

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Published inCurrent pharmaceutical design Vol. 24; no. 39; p. 4646
Main Authors Javadinia, Seyed A, Shahidsales, Soodabeh, Fanipakdel, Azar, Mostafapour, Asma, Joudi-Mashhad, Mona, Ferns, Gordon A, Avan, Amir
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2018
Subjects
microRNAs
translation
PI3K/AKT/mTOR pathway
esophageal cancer
transcription
rapamycin
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Summary:The Phosphatidylinositol 3-kinase/AKT/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) pathway has a critical regulatory role in cell biology including translation, transcription, and autophagy. Dysregulation of this pathway is involved in the pathogenesis, development, and prognosis of esophageal cancer that has been assessed in the recent years and its potential as a target in therapy. This report summarizes the current knowledge about PI3K/AKT/mTOR pathway and its cross-talk with a focus on the value of targeting this pathway as a potential therapeutic target in the treatment of esophageal cancer.
ISSN:1873-4286
DOI:10.2174/1381612825666190110143258