Microwave-Assisted Polymer-Supported Combinatorial Synthesis

Lead identification and optimization is always a challenge to the medicinal chemists in drug discovery. Numbers of simple to complex and smaller to bigger organic compounds are prepared to meet the screening purpose of biological targets. Conventional solution phase synthetic methodologies are lacki...

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Published inCurrent medicinal chemistry Vol. 10; no. 22; pp. 2403 - 2423
Main Authors SWAMY, K. M. K, YEH, Wen-Ben, LIN, Mei-Jung, SUN, Chung-Ming
Format Journal Article
LanguageEnglish
Published Schiphol Bentham Science Publishers Ltd 01.11.2003
Bentham Science
Subjects
Biological and medical sciences
Combinatorial Chemistry Techniques - methods
General pharmacology
Heating
Medical sciences
Microwaves
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Polymers - chemical synthesis
Polymers - chemistry
Solvents - chemistry
Automation
Purine derivatives
Peptides
Knoevenagel condensation
Nitrogen heterocycle
Ugi reaction
Combinatorial chemistry
Polymer
Review
Liquid phase
Microwave heating
Imide
Chemical compound library
Triazine derivatives
Solid phase
Reaction support
Claisen rearrangement
Nucleophilic substitution
Chemical synthesis
Enone
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Summary:Lead identification and optimization is always a challenge to the medicinal chemists in drug discovery. Numbers of simple to complex and smaller to bigger organic compounds are prepared to meet the screening purpose of biological targets. Conventional solution phase synthetic methodologies are lacking the speed to run along with the need of medicinally interesting compounds due to their long reaction time, tedious work-up and purification problems. Alternatively opted polymersupported synthesis of combinatorial libraries has been emerged as a promising tool in generating large numbers of structurally diverse molecules in a manner rapidand parallel. Microwave-assisted solid / liquid phase combinatorial synthetic techniques have been proved efficient in reducing the reaction time from days & hours to minutes & seconds and more promisingly to produce improved yields with high purities. This review briefs about the theory behind microwave chemical technology and glimpses of recent advancements in its application on polymer supported combinatorial synthesis.
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ISSN:0929-8673
1875-533X
DOI:10.2174/0929867033456594