T cell lymphoid aggregates in bone marrow in idiopathic hypereosinophilic syndrome

• Published in: Journal of clinical pathology Vol. 46; no. 10; pp. 955 - 958
• Main Authors: Metz, J, McGrath, K M, Savoia, H F, Begley, C G, Chetty, R
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.10.1993; BMJ; BMJ Publishing Group LTD
• Subjects: Biological and medical sciences; Bone Marrow - pathology; Cell Aggregation; Eosinophilia - pathology; Eosinophils - pathology; Granulocyte-Macrophage Colony-Stimulating Factor - analysis; Hematologic and hematopoietic diseases; Humans; Male; Medical sciences; Middle Aged; Other diseases. Hematologic involvement in other diseases; T-Lymphocytes - pathology; Human; Cytokine; Granulocyte; Idiopathic; Malignant hemopathy; Hemopathy; Eosinophilia; Differential diagnostic; Eosinophil; Case study; Pathology; Interleukin 5; Lymphoproliferative syndrome; T-Lymphocyte; Bone marrow; Malignant lymphoma
• ISSN: 0021-9746; 1472-4146
• DOI: 10.1136/jcp.46.10.955

Idiopathic hypereosinophilic syndrome (HES) comprises a heterogeneous group of disorders characterised by prolonged eosinophilia with no obvious cause. A patient with longstanding HES is reported in whom unusual non-neoplastic peritrabecular lymphoid aggregates were present in the bone marrow, a hitherto undescribed association, as far as is known. An eosinophil colony stimulating activity was detected in the serum. The findings in this patient provide further evidence for an important role for eosinophil colony stimulating activity interleukin-5 mediated T lymphocyte control of eosinophil production in the pathogenesis of the HES.