Effects of Age, Sex, and Polycystic Disease on Progressive Bone Disease of Renal Failure

• Published in: British Medical Journal Vol. 4; no. 5944; pp. 557 - 560
• Main Authors: Moorhead, J. F., Tatler, G. L. V., Baillod, R. A., Varghese, Z., Wills, M. R., Farrow, S. C.
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 07.12.1974; British Medical Association; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; Age Factors; Age groups; Bone diseases; Bone Diseases - etiology; Bone fractures; Bone Resorption - etiology; Calcinosis - etiology; Child; Child, Preschool; Dialysis; Disease progression; Female; Fractures, Bone - etiology; Humans; Infant; Infant, Newborn; Kidney Failure, Chronic - complications; Lesions; Male; Men; Middle Aged; Papers and Originals; Polycystic Kidney Diseases - complications; Radiology; Renal Dialysis; Sex Factors; Time Factors; Vascular calcification; Vascular diseases; Vascular Diseases - etiology
• ISSN: 0007-1447; 1468-5833
• DOI: 10.1136/bmj.4.5944.557

A study of 150 patients undergoing haemodialysis has shown that age had a striking effect on the radiological presentation of renal bone disease, erosions being common in the young and uncommon in older patients and vascular calcification showing opposite trends to this. Men aged 20 to 59 years had a greater tendency to develop erosions than did women in this age range. Examination of a group of 53 patients over a period of five years showed that the half time for the development of vascular calcification was 4·6 years, erosions 26·7 years, and fractures 6·9 years. Nine out of 16 polycystic patients matched for age and sex with 50 controls did not develop erosions and had consistently less vascular calcification than the controls when examined over a six-year period.