Role of adipokines and cytokines in non-alcoholic fatty liver disease

One of the most common hepatic manifestations of the metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This disease varies from simple steatosis to cirrhosis and hepatocellular carcinoma. Different molecules secreted from adipose tissue such as adiponectin, leptin, resistin and visfat...

Full description

Saved in:
Bibliographic Details
Published inReviews on recent clinical trials Vol. 9; no. 3; p. 134
Main Authors Abenavoli, Ludovico, Peta, Valentina
Format Journal Article
LanguageEnglish
Published United Arab Emirates 26.01.2015
Subjects
Adipokines - physiology
Cytokines - physiology
Humans
Non-alcoholic Fatty Liver Disease - etiology
Online AccessGet more information

Cover

More Information
Summary:One of the most common hepatic manifestations of the metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This disease varies from simple steatosis to cirrhosis and hepatocellular carcinoma. Different molecules secreted from adipose tissue such as adiponectin, leptin, resistin and visfatin and pro-inflammatory cytokines such as tumour necrosis factor-α, and interleukins, can be involved in the pathogenesis of NAFLD. In this review we describe the role of these adipokines and cytokines in the pathogenesis of NAFLD. We comment on their potential use as non-invasive biomarkers of steatosis and fibrosis, and their potential therapeutic role.
ISSN:1876-1038
DOI:10.2174/1574887109666141216102458