Functional genomics in gastroenterology

• Published in: Gut Vol. 47; no. 5; pp. 601 - 607
• Main Authors: SCHREIBER, S, HAMPE, J, EICKHOFF, H, LEHRACH, H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.11.2000; BMJ; BMJ Publishing Group LTD
• Subjects: Biological and medical sciences; Biological evolution; Biology; Biotechnology - trends; Chromosome Mapping; Crohns disease; Data analysis; Expressed Sequence Tags; Forecasting; Fundamental and applied biological sciences. Psychology; Gangrene; Gastrointestinal Diseases - genetics; Gene expression; Gene Library; Genetic Linkage; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human; Genomics; Hospitals; Humans; Hypotheses; Image Processing, Computer-Assisted; Immunology; Inflammation; Inflammatory bowel disease; Leading; Medical research; Pharmacogenetics; Proteins; Publication Bias; Tumor necrosis factor-TNF; Human; Biotechnology; Perspective; Pathogenesis; Technology; Scientific research; Gastroenterology; Evolution; Genetics; Public health
• ISSN: 0017-5749; 1468-3288; 1458-3288
• DOI: 10.1136/gut.47.5.601

Exploration of signalling cascades and their role in disease pathophysiology has reached an enormous degree of complexity. [...]distinction between primary and secondary events is impossible in most cases. Recognised patterns are prone to false positivity because of their complexity and the multiple testing involved. [...]the consequent replication and verification of any results in independent and well characterised secondary cohorts and experimental set ups (for pathophysiology) is imperative.