Prognosis of primary ab externo surgery for primary congenital glaucoma

• Published in: British journal of ophthalmology Vol. 83; no. 3; pp. 317 - 322
• Main Authors: Dietlein, Thomas S, Jacobi, Philipp C, Krieglstein, Günter K
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.03.1999; BMJ; BMJ Publishing Group LTD
• Subjects: Age Factors; Antibiotics; Biological and medical sciences; Child, Preschool; Eye - pathology; Female; Follow-Up Studies; Glaucoma; Glaucoma - congenital; Glaucoma - pathology; Glaucoma - surgery; Humans; Infant; Infant, Newborn; Life expectancy; Male; Medical prognosis; Medical sciences; Methods; Original; primary congenital glaucoma; Prognosis; Retrospective Studies; Risk Factors; Software; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; trabeculectomy; Trabeculectomy - adverse effects; Trabeculectomy - methods; trabeculotomy; Treatment Outcome; Human; Trabeculectomy; Prognosis; Congenital; Surgical drainage; Aqueous humor; Congenital disease; Eye disease; Newborn; Treatment; Glaucoma (eye); Surgery; Technique
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.83.3.317

BACKGROUND The strategy of pressure reducing surgery in primary congenital glaucoma has changed over the last decade. Ab externo filtering procedures—for example, trabeculectomy or trabeculotomy combined with trabeculectomy, have now been accepted even as primary intervention. METHODS The authors reviewed 61 eyes in 35 consecutive patients with primary congenital glaucoma, who underwent different types of initial ab externo surgery between 1988 and 1996 (median follow up 36 months) to determine the efficacy of different surgical techniques and the influence of various risk factors. RESULTS Trabeculotomy was performed in 17 eyes (27.9%), trabeculotomy with trabeculectomy in 15 eyes (24.6%), and trabeculectomy in 29 eyes (47.5%). Regarding age, preoperative intraocular pressure, corneal diameter, ocular axial length, and incidence of corneal haze the subgroups were comparable. Success rates of trabeculotomy, trabeculectomy, and a combined procedure did not significantly differ when assessed by life table analysis. Patient age under 3 months (p=0.014) and an ocular axial length of 24 mm or more (p=0.016) proved to be major risk factors for primary ab externo surgery failure. A second operation was necessary in 20 of 61 eyes (32.8%) during follow up. CONCLUSION Prognosis of primary ab externo glaucoma surgery in primary congenital glaucoma seems to be governed more by the individual course and severity of the disease than by modification of surgical techniques.