Combined Test for Assessment of Anterior Pituitary Function

• Published in: British Medical Journal Vol. 4; no. 5888; pp. 326 - 329
• Main Authors: Harsoulis, P., Marshall, J. C., Kuku, S. F., Burke, C. W., London, D. R., Fraser, T. R.
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 10.11.1973; British Medical Association; BMJ Publishing Group LTD
• Subjects: Acromegaly; Anterior pituitary; Blood Glucose; Diabetic retinopathy; Disorders; Endocrinology; Follicle Stimulating Hormone - blood; Gonadotropin-Releasing Hormone; Growth Hormone - blood; Growth hormones; Hormones; Humans; Hydrocortisone - blood; Immunoassay; Insulin; Luteinizing Hormone - blood; Male; Medical journals; Methods; Papers and Originals; Pituitary Diseases - physiopathology; Pituitary Function Tests; Pituitary Gland - metabolism; Pituitary Neoplasms - physiopathology; Secretion; Stimulation, Chemical; Thyrotropin - blood; Thyrotropin-Releasing Hormone; Time Factors
• ISSN: 0007-1447; 1468-5833
• DOI: 10.1136/bmj.4.5888.326

A combined test consisting of the simultaneous administration of insulin, thyrotrophin-releasing hormone (TRH), and luteinizing hormone and follicle stimulating hormone-releasing hormone (LH/FSH-RH) was performed in 24 people. Eleven of these also had the three individual tests performed separately, and the remaining 13 had a separate test of either LH/FSH-RH and TRH together or singly at a later date. In both normal people and patients, whether the tests were performed alone or in combination, no difference was found between the hormone responses (growth hormone, cortisol, LH, FSH, thyroid-stimulating hormone) seen to these stimuli. It is proposed that combined administration of insulin and the hypothalamic releasing hormones may be used as a single test for the assessment of anterior pituitary function. The test is convenient and time saving, and with care can be performed in outpatients.