Interferon associated retinopathy

• Published in: British Journal of Ophthalmology Vol. 82; no. 3; pp. 323 - 325
• Main Authors: HAYASAKA, SEIJI, NAGAKI, YASUNORI, MATSUMOTO, MASAYUKI, SATO, SHOICHI
• Format: Journal Article Book Review
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.03.1998; BMJ; BMJ Publishing Group LTD
• Subjects: Animals; Antiviral Agents - adverse effects; Biological and medical sciences; Diabetes; Drug toxicity and drugs side effects treatment; Hepatitis; Humans; Incidence; Interferon; Interferons - adverse effects; Medical sciences; Pathogenesis; Pharmacology. Drug treatments; Rabbits; Retinal Diseases - etiology; Risk Factors; Sarcoidosis; Toxicity; Toxicity: eye; Vision Disorders - etiology; Japan; Human; Eye disease; Retinopathy; Toxicity; Cytokine; Interferon; Review
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.82.3.323

[...]these authors did not mention the ocular toxicity. 14 Typical interferon associated retinopathy In 1990, Ikebe and associates 15 first reported a 39 year old patient with retinal haemorrhages and cotton wool spots following intravenous administration of interferon. Since 1992, interferon therapy for viral hepatitis has been used at many hospitals in Japan; there are possibly more than 1.6 million patients with type C hepatitis in Japan and interferon use has been allowed by Health Insurance of Japan. Since 1993, ocular complications following interferon therapy have been reported mainly in Japan, 16-47 although Bauherz and associates, 48 Guyer and coworkers, 11 Kloseet al, 49 and Vegh et al 50 have also demonstrated interferon associated ocular toxicity.