Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study

• Published in: BMJ open Vol. 9; no. 4; p. e025909
• Main Authors: Vourc’h, Mickael, Huard, Donatien, Feuillet, Fanny, Baud, Gabrielle, Guichoux, Arthur, Surbled, Marielle, Tissot, Melanie, Chiffoleau, Anne, Guitton, Christophe, Jaber, Samir, Asehnoune, Karim
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group LTD 25.04.2019; BMJ Publishing Group
• Subjects: Airway management; Airway Management - instrumentation; Airway Management - methods; Anaesthesia; Anesthesia; Anesthesiology; Cannula; Humans; Intensive care; Intubation; Laryngoscopy; Life Sciences; Masks; Medical personnel; Nose; Oxygen Inhalation Therapy - methods; Patient safety; Performance evaluation; Prospective Studies; Randomized Controlled Trials as Topic - methods; Research Design; Respiratory therapy; Systematic review; Task forces; Ventilators; apneic oxygenation; anticipated difficult intubation; fiberoptic intubation; high-flow nasal cannula; video-laryngoscopy
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2018-025909

IntroductionAlthough preoxygenation and airway management respond to precise algorithms, difficult intubation (DI) remains a daily challenge in intensive care units and in the operating rooms because of its frequent complications, including hypoxaemia. To prevent desaturation during DI, high-flow oxygenation by nasal cannula (HFNC) could prove beneficial. Indeed, contrary to standard preoxygenation device, it can be held in place throughout the intubation trying to perform apnoeic oxygenation during DI. Hence, recent guidelines recommend HFNC during DI, but its relevance has never been evaluated in this setting in a large randomised study until now.Methods and analysisThe PREOPTIDAM trial is a prospective, single-centre, randomised, controlled study in Nantes University Hospital. In anticipated DI, we hypothesised that HFNC can decrease the incidence of desaturation ≤94% or face mask ventilation from 16% to 4% compared with standard device. Using a two-sided t-test with a first species risk of 5% and 80% power, a total of 186 patients will be included. Using a computer-generated randomisation, with a 1:1 allocation ratio, patients will be randomised to HFNC or face mask preoxygenation. Randomisation will be stratified on intubation sequence: Rapid sequence intubation or awake fibreoptic intubation. The primary objective is to determine whether HFNC is more efficient than standard oxygenation techniques to prevent desaturation ≤94% or face mask ventilation during DI. Intent-to-treat and per-protocol analysis are planned for the primary outcome.Ethics and disseminationThe study project has been approved by an independent ethics committee. Written informed consent will be obtained before study inclusion. Participant recruitment begins in September 2018. Results will be submitted to international peer-reviewed medical journals.Trial registration number NCT03604120.