Parallel interleukin 5 synthesis by eosinophils in duodenal and skin lesions of a patient with dermatitis herpetiformis

• Published in: Gut Vol. 37; no. 1; pp. 132 - 135
• Main Authors: Desreumaux, P, Janin, A, Delaporte, E, Dubucquoi, S, Piette, F, Cortot, A, Capron, M, Colombel, J F
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.1995; BMJ; BMJ Publishing Group LTD
• Subjects: Biological and medical sciences; Dermatitis Herpetiformis - metabolism; Dermatitis Herpetiformis - pathology; Duodenum - pathology; Eosinophils - metabolism; Human viral diseases; Humans; Immunohistochemistry; In Situ Hybridization; Infectious diseases; Interleukin-5 - biosynthesis; Intestinal Mucosa - metabolism; Male; Medical sciences; Microscopy, Electron; Middle Aged; Skin - pathology; Viral diseases; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye; Bullous dermatosis; Human; Immunopathology; Skin disease; Correlation; Duodenal disease; Cytokine; Autoimmune disease; Gene expression; Dermatitis herpetiformis; Eosinophil; Case study; Interleukin 5; Messenger RNA; Digestive diseases; Intestinal disease
• ISSN: 0017-5749; 1468-3288; 1458-3288
• DOI: 10.1136/gut.37.1.132

A 59 year old man is presented with a diagnosis of dermatitis herpetiformis. Duodenal and skin biopsy specimens from blisters of both recent and late onset were collected before treatment. Electron microscopy, immunohistochemistry, and in situ hybridisation were performed to analyse the presence of activated eosinophils and the local synthesis of interleukin 5 (IL5). Parallel state of eosinophil activation and IL5 synthesis was found in the duodenal mucosa with total flat mucosa and in skin vesicles of recent onset. It is suggested that duodenal and cutaneous eosinophils can synthesise IL5 and then participate in small bowel and skin lesions.