Models of breast cancer: is merging human and animal models the future?

Survival rates of patients with early breast cancer in the United Kingdom and in the United States have improved steadily over the past 15 years. The only way to continue or even accelerate this progress, however, is the discovery and development of new preventative and therapeutic strategies. With...

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Bibliographic Details
Published inBreast cancer research : BCR Vol. 6; no. 1; pp. 22 - 30
Main Authors Kim, Jong B, O'Hare, Michael J, Stein, Robert
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 01.01.2004
National Library of Medicine - MEDLINE Abstracts
BioMed Central
Subjects
Analysis
Animals
B cells
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - prevention & control
Disease Models, Animal
Female
Humans
Mammary Neoplasms, Experimental - genetics
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - prevention & control
Mice
Mice, Nude
Mice, SCID
Mice, Transgenic
Neoplasm Transplantation
Xenograft Model Antitumor Assays
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Summary:Survival rates of patients with early breast cancer in the United Kingdom and in the United States have improved steadily over the past 15 years. The only way to continue or even accelerate this progress, however, is the discovery and development of new preventative and therapeutic strategies. With the massive explosion in potential therapeutic strategies becoming available, in the postgenomic era, better and more representative breast cancer models are urgently required for preclinical trials. Development of better in vivo models of human breast cancer are thus of crucial importance in the development of new cancer therapeutics.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ObjectType-Article-3
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/bcr645