Human progenitor cells for bone engineering applications

In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human...

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Bibliographic Details
Published inCurrent molecular medicine Vol. 13; no. 5; p. 723
Main Authors de Peppo, G M, Thomsen, P, Karlsson, C, Strehl, R, Lindahl, A, Hyllner, J
Format Journal Article
LanguageEnglish
Published Netherlands 01.06.2013
Subjects
Adult Stem Cells - transplantation
Animals
Bone Diseases, Metabolic - therapy
Bone Regeneration
Cell Differentiation
Embryonic Stem Cells - transplantation
Humans
Osteogenesis
Regenerative Medicine
Tissue Engineering
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Summary:In this report, the authors review the human skeleton and the increasing burden of bone deficiencies, the limitations encountered with the current treatments and the opportunities provided by the emerging field of cell-based bone engineering. Special emphasis is placed on different sources of human progenitor cells, as well as their pros and cons in relation to their utilization for the large-scale construction of functional bone-engineered substitutes for clinical applications. It is concluded that, human pluripotent stem cells represent a valuable source for the derivation of progenitor cells, which combine the advantages of both embryonic and adult stem cells, and indeed display high potential for the construction of functional substitutes for bone replacement therapies.
ISSN:1875-5666
DOI:10.2174/1566524011313050004