study of the early morphological changes initiated in the uterine luminal epithelium by substances (oil and carrageenan) which induce the decidual cell reaction in mice

Oil, carrageenan or saline were injected into the uteri of ovariectomized mice treated with hormones on schedules which would sensitize, partly sensitize or not sensitize the uterus to an intraluminal decidual stimulus. The uterine epithelium was examined histologically at various times over the suc...

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Bibliographic Details
Published inJournal of reproduction & fertility Vol. 86; no. 2; pp. 619 - 626
Main Authors Finn, C.A, Pope, M.D, Milligan, S.R
Format Journal Article
LanguageEnglish
Published England Society for Reproduction and Fertility 01.07.1989
Subjects
anatomy and morphology
Animals
Arachis
carrageenan
Carrageenan - pharmacology
Decidua - drug effects
endometrium
epithelium
Epithelium - drug effects
Epithelium - ultrastructure
Estradiol - pharmacology
Female
Mice
Microscopy, Electron
oils
Peanut Oil
Plant Oils - pharmacology
Progesterone - pharmacology
uterus
Uterus - drug effects
Uterus - ultrastructure
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Summary:Oil, carrageenan or saline were injected into the uteri of ovariectomized mice treated with hormones on schedules which would sensitize, partly sensitize or not sensitize the uterus to an intraluminal decidual stimulus. The uterine epithelium was examined histologically at various times over the succeeding 5 h. Saline did not produce any morphological change whereas almost immediately after the injection of oil or carrageenan epithelial cell death was apparent in the uterus, regardless of hormone treatment. Within 45 min the dead cells had been removed and the epithelium was re-established. Oil droplets were still present in the uterus after 5 h and these were able to stimulate a decidual reaction in partly sensitized animals when oestrogen was administered 18–44 h after the oil instillation, well after the re-establishment of the epithelium. It is suggested that the early transient cell death in the uterine epithelium is not responsible for triggering the decidual reaction but that it is the contact of the oil droplet with an intact epithelium which triggers the response when the hormonal conditions so allow. Keywords: decidualization; uterus; implantation; endometrium; mouse
ISSN:0022-4251
1470-1626
1741-7899
DOI:10.1530/jrf.0.0860619