Blood–brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: an in vitro study

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 84; no. 7; pp. 756 - 765
• Main Authors: Saito, Kazuyuki, Shimizu, Fumitaka, Koga, Michiaki, Sano, Yasuteru, Tasaki, Ayako, Abe, Masaaki, Haruki, Hiroyo, Maeda, Toshihiko, Suzuki, Seiko, Kusunoki, Susumu, Mizusawa, Hidehiro, Kanda, Takashi
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.07.2013; BMJ Publishing Group LTD
• Subjects: Antibodies; Antibodies, Blocking - pharmacology; Antibodies, Blocking - therapeutic use; Ataxia; BLOOD-BRAIN BARRIER; Blood-Brain Barrier - pathology; Blood-Nerve Barrier - pathology; Blotting, Western; Capillaries - pathology; Cells, Cultured; Dipeptides - pharmacology; Electric Impedance; Encephalitis - blood; Encephalitis - pathology; Endothelial Cells - metabolism; Enzyme-Linked Immunosorbent Assay; GANGLIOSIDE; GUILLAIN-BARRE SYNDROME; Humans; Immunoglobulin G - isolation & purification; Indicators and Reagents; Matrix Metalloproteinase 9 - metabolism; Matrix Metalloproteinases - metabolism; Membranes; Miller Fisher Syndrome - blood; Miller Fisher Syndrome - metabolism; Miller Fisher Syndrome - pathology; Nervous system; NEUROIMMUNOLOGY; Patients; Phenotype; Protease Inhibitors - pharmacology; Serum; Tight Junctions - physiology; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Minnesota; California; United Kingdom > UK; United States > US; GUILLAIN-BARRE SYNDROME; BLOOD-BRAIN BARRIER; GANGLIOSIDE; NEUROIMMUNOLOGY

Objective To ascertain the hypothesis that the phenotypic differences between Bickerstaff's brainstem encephalitis (BBE) and Miller Fisher syndrome (MFS) are derived from the differences in the effects of sera on blood–brain barrier (BBB) and blood–nerve barrier. Background Antibodies against G...