The Role of Bioreactors in Ligament and Tendon Tissue Engineering

Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Mod...

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Bibliographic Details
Published inCurrent stem cell research & therapy Vol. 11; no. 1; p. 35
Main Authors Mace, James, Wheelton, Andy, Khan, Wasim S, Anand, Sanj
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.01.2016
Subjects
Bioreactors
Cell Differentiation
Humans
Ligaments
Pluripotent Stem Cells - physiology
Tendons
Tissue Engineering - methods
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Summary:Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.
ISSN:2212-3946
DOI:10.2174/1574888X10666150904113827