Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth
A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to preven...
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Published in | Current drug targets Vol. 17; no. 12; p. 1414 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United Arab Emirates
01.09.2016
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Subjects | |
Online Access | Get more information |
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Summary: | A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells. |
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ISSN: | 1873-5592 |
DOI: | 10.2174/1389450116666150506112817 |