Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth

• Published in: Current drug targets Vol. 17; no. 12; p. 1414
• Main Authors: Stevens, An-Sofie, Pirotte, Nicky, Wouters, Annelies, Van Roten, Andromeda, Van Belleghem, Frank, Willems, Maxime, Cuypers, Ann, Artois, Tom, Smeets, Karen
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.09.2016
• Subjects: Animals; Antineoplastic Agents - pharmacology; Cell Survival - drug effects; Cell Transformation, Neoplastic; Drug Design; Humans; Molecular Targeted Therapy; Neoplasms - drug therapy; Neoplasms - pathology; Oxidation-Reduction; Regeneration - physiology
• ISSN: 1873-5592
• DOI: 10.2174/1389450116666150506112817

A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells.