Diversity scaling of human vaginal microbial communities

• Published in: Dōngwùxué yánjiū Vol. 40; no. 6; pp. 587 - 594
• Main Authors: Li, Wendy, Ma, Zhan-Shan Sam
• Format: Journal Article
• Language: English
• Published: China Kunming Institute of Zoology, The Chinese Academy of Sciences 18.11.2019
• Subjects: Aetiology; Bacteria - classification; Biodiversity; Biogeography; Cesarean section; Childbirth & labor; Cohorts; Epidemiology; Etiology; Female; Heterogeneity; HIV; Human immunodeficiency virus; Humans; Infections; Metabolism; Microbial activity; Microbiomes; Microbiota; Microorganisms; Miscarriage; Order parameters; Population; Postpartum; Postpartum Period; Pregnancy; Premature birth; Profiles; Scaling; Species-area relationship; Stability; Studies; Trends; Vagina; Vagina - microbiology; Vaginosis; Viral infections; Women; Womens health; Microbiome diversity heterogeneity; SAR (species-area relationship); DAR (diversity-area relationship); Microbiome diversity scaling; Human vaginal microbiome
• ISSN: 2095-8137; 0254-5853
• DOI: 10.24272/j.issn.2095-8137.2019.068

The composition and diversity of the human vaginal microbial community have been investigated intensively due to the diversity-stability relationship (DSR)-based hypothesis for bacterial vaginosis (BV) etiology, which was first proposed in the 1990s and has received renewed interest in recent years. Nevertheless, diversity changes (scaling) across individuals in a cohort or population have not yet been addressed, which is significant both theoretically and practically. Theoretically, biodiversity scaling is the core of biogeography, and practically, inter-subject heterogeneity is critical for understanding the etiology and epidemiology of human microbiome-associated diseases such as BV. Here we applied the diversity-area relationship (DAR), a recent extension to the classic species-area relationship (SAR), to study diversity scaling of the vaginal microbiome by reanalyzing reported data collected from 1 107 postpartum women. The model used here characterized the power-law (or its extension) relationships between accrued diversity and areas (numbers of individuals), upon which four biogeographic profiles were thus defined. Specifically, we established the DAR profile (relationship between diversity scaling parameter and so-termed diversity order ( )), similarly pair-wise diversity overlap (PDO) profile, maximal accrual diversity (MAD) profile, and ratio of individual-level to population-level diversity (RIP) profile. These four profiles offer valuable tools to assess and predict diversity scaling (changes) in the human vaginal microbiome across individuals, as well as to understand the dynamics of vaginal microbiomes in healthy women.