The role of PEDF in tumor growth and metastasis

• Published in: Current molecular medicine Vol. 10; no. 3; p. 292
• Main Authors: Hoshina, D, Abe, R, Yamagishi, S-I, Shimizu, H
• Format: Journal Article
• Language: English
• Published: Netherlands 01.04.2010
• Subjects: Angiogenesis Inhibitors - metabolism; Angiogenesis Inhibitors - therapeutic use; Apoptosis - physiology; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Endothelium, Vascular - physiology; Eye Proteins - metabolism; Eye Proteins - therapeutic use; fas Receptor - metabolism; Humans; Neoplasm Metastasis - drug therapy; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic - drug therapy; Nerve Growth Factors - metabolism; Nerve Growth Factors - therapeutic use; Protease Inhibitors - metabolism; Protease Inhibitors - therapeutic use; Serpins - metabolism; Serpins - therapeutic use; Signal Transduction - physiology
• ISSN: 1875-5666
• DOI: 10.2174/156652410791065327

Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.