A flowgraph model for bladder carcinoma

Superficial bladder cancer has been the subject of numerous studies for many years, but the evolution of the disease still remains not well understood. After the tumor has been surgically removed, it may reappear at a similar level of malignancy or progress to a higher level. The process may be reas...

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Bibliographic Details
Published inTheoretical biology and medical modelling Vol. 11 Suppl 1; no. S1; p. S3
Main Authors Rubio, Gregorio, García-Mora, Belén, Santamaría, Cristina, Pontones, José Luis
Format Journal Article
LanguageEnglish
Published England BioMed Central 07.05.2014
BioMed Central Ltd
Subjects
Bioinformatics
Biomedical engineering
Bladder
Disease Progression
Hospitals
Humans
Markov analysis
Markov Chains
Models, Biological
Neoplasm Recurrence, Local - pathology
Random variables
Survival analysis
Urinary Bladder - pathology
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Summary:Superficial bladder cancer has been the subject of numerous studies for many years, but the evolution of the disease still remains not well understood. After the tumor has been surgically removed, it may reappear at a similar level of malignancy or progress to a higher level. The process may be reasonably modeled by means of a Markov process. However, in order to more completely model the evolution of the disease, this approach is insufficient. The semi-Markov framework allows a more realistic approach, but calculations become frequently intractable. In this context, flowgraph models provide an efficient approach to successfully manage the evolution of superficial bladder carcinoma. Our aim is to test this methodology in this particular case. We have built a successful model for a simple but representative case. The flowgraph approach is suitable for modeling of superficial bladder cancer.
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ISSN:1742-4682
1742-4682
DOI:10.1186/1742-4682-11-S1-S3