Corticotropin-releasing factor binding protein--a ligand trap?

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognit...

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Published inMini reviews in medicinal chemistry Vol. 5; no. 10; p. 953
Main Authors Jahn, Olaf, Radulovic, Jelena, Stiedl, Oliver, Tezval, Hossein, Eckart, Klaus, Spiess, Joachim
Format Journal Article
LanguageEnglish
Published Netherlands 01.10.2005
Subjects
Amino Acid Sequence
Animals
Binding Sites
Carrier Proteins - antagonists & inhibitors
Carrier Proteins - chemistry
Cognition Disorders - drug therapy
Corticotropin-Releasing Hormone - chemistry
Corticotropin-Releasing Hormone - metabolism
Humans
Ligands
Molecular Sequence Data
Receptors, Corticotropin-Releasing Hormone - chemistry
Receptors, Corticotropin-Releasing Hormone - metabolism
Urocortins
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Summary:The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.
ISSN:1389-5575
1875-5607
DOI:10.2174/138955705774329500