Plasma concentrations of 1-deamino-8-d-arginine vasopressin after intragastric administration in the rat

A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained. The immunoidentity of plasma DDAVP an...

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Bibliographic Details
Published inActa endocrinologica (Copenhagen) Vol. 108; no. 2; pp. 179 - 183
Main Authors Lundin, S, Melin, P, Vilhardt, H
Format Journal Article
LanguageEnglish
Published Denmark 01.02.1985
Subjects
Animals
Arginine Vasopressin - blood
Chromatography, High Pressure Liquid
Cross Reactions
Deamino Arginine Vasopressin - administration & dosage
Deamino Arginine Vasopressin - blood
Deamino Arginine Vasopressin - immunology
Female
PITUITARY
Radioimmunoassay
Rats
Rats, Brattleboro
Rats, Inbred Strains
Stomach
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Summary:A sensitive and specific radioimmunoassay for 1-deamino-8-d-arginine vasopressin (DDAVP) was developed. Plasma concentrations of DDAVP after intragastric administration were determined in non-fasted rats and a dose-related increase in plasma levels was obtained. The immunoidentity of plasma DDAVP and standard was established by high performance liquid chromatography (HPLC). Correlation of biological and immunological responses of DDAVP was assessed using the antidiuretic effect in the Brattleboro (diabetes insipidus) rat.
ISSN:0804-4643
0001-5598
1479-683X
DOI:10.1530/acta.0.1080179