Spatiotemporal distribution characteristics and impact factors of hepatitis C in Chongqing, China, 2014–2020

• Published in: BMJ open Vol. 14; no. 12; p. e077935
• Main Authors: Chen, Saijuan, Wang, Qiuting, An, Yunyi, Chen, Ying, Liu, Hua, Tan, Weijie, Zhou, Xinyun, Xing, Dianguo, Zhang, Yan
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 23.12.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adolescent; Adult; Age Distribution; Age groups; Aged; Bayes Theorem; Child; Child, Preschool; China - epidemiology; Disease prevention; Epidemiology; Female; Gender; Hepatitis C; Hepatitis C - epidemiology; Humans; Incidence; Infant; Infections; INFECTIOUS DISEASES; Male; Middle Aged; Original Research; Per capita; Population density; Prevalence; Public Health; Regions; Risk Factors; Sex Distribution; Socioeconomic factors; Software; Spatio-Temporal Analysis; Trends; Urban areas; Urban Population - statistics & numerical data; Variables; Young Adult; China; INFECTIOUS DISEASES; Epidemiology; Public health
• ISSN: 2044-6055; 2044-6055
• DOI: 10.1136/bmjopen-2023-077935

ObjectivesThis study aimed to explore the spatial and temporal distribution of hepatitis C and its influencing factors in Chongqing, providing a scientific basis for the relevant departments to formulate targeted preventive measures for the high prevalence of hepatitis C in the region and population.DesignWe collected data on hepatitis C cases in Chongqing (located in the southwest of China) from 2014 to 2020, and analysed the spatiotemporal heterogeneity of hepatitis C incidence in different populations and identified factors that might influence the incidence of hepatitis C by constructing a Bayesian spatiotemporal model.SettingsThe study subjects included clinically diagnosed cases and confirmed cases of hepatitis C with current address in Chongqing and onset date between 1 January 2014 and 31 December 2020.ParticipantsThe study used aggregated data, including 33 900 clinically diagnosed cases and confirmed cases of hepatitis C.ResultsFrom 2014 to 2020, the high-risk areas of hepatitis C were primarily concentrated in the main and new urban areas of Chongqing. In contrast, the low-risk areas were mainly found in southeast and northeast Chongqing. There was also an increasing trend in the risk of incidence in the low-risk areas. Analysis of different populations revealed that men aged 45–59 years had a higher risk of developing hepatitis C in the main urban area compared with other age groups. Additionally, the risk for this population group showed an increasing trend in the southeast and northeast of Chongqing as well as the main urban area. Among women, the rising trend of hepatitis C risk was stronger for those aged 30–44 years in southeast Chongqing and for those aged 45–59 years in northeast Chongqing compared with other age groups. The analysis of influencing factors found that gross domestic product per capita, population density and the proportion of tertiary industry were associated with an increased risk of hepatitis C.ConclusionsHigh-risk areas for hepatitis C virus were mainly located in the main and new urban areas of Chongqing, where the male prime-age population was the focus of prevention and treatment. In the future, the relevant authorities should concentrate on high-risk areas and at the same time strengthen screening and serological surveys for hepatitis C in low-risk areas and various populations, and raise public awareness of prevention, so as to reduce the incidence of hepatitis C.