Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease

Beta-amyloid (Abeta)likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, Abeta associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of Abeta formation and then discu...

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Bibliographic Details
Published inMini reviews in medicinal chemistry Vol. 8; no. 5; p. 429
Main Authors Bastianetto, S, Krantic, S, Quirion, R
Format Journal Article
LanguageEnglish
Published Netherlands 01.05.2008
Subjects
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Amyloid beta-Peptides - antagonists & inhibitors
Amyloid beta-Peptides - metabolism
Animals
Flavonoids - chemistry
Flavonoids - pharmacology
Humans
Molecular Structure
Phenols - chemistry
Phenols - pharmacology
Polyphenols
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Summary:Beta-amyloid (Abeta)likely plays a pivotal role in the etiology of Alzheimer's disease (AD). Consequently, Abeta associated pathways are targets for the development of possible effective AD therapies. This review first updates strategies aimed at the inhibition of Abeta formation and then discusses the role of food-derived polyphenols as putative anti-amyloid drugs.
ISSN:1389-5575
DOI:10.2174/138955708784223512