Diabetes insipidus, diabetes mellitus, optic atrophy and deafness. A clinical and genetic study

Two Iraqi sisters and a female cousin developed diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA), and deafness (D), (the 'DIDMOAD' syndrome) before the age of 12 years. One girl exhibited all the features of this disease complex only 3 months after an unusually late onse...

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Bibliographic Details
Published inPostgraduate medical journal Vol. 55; no. 644; pp. 377 - 380
Main Author Nagi, N. A.
Format Journal Article
LanguageEnglish
Published England The Fellowship of Postgraduate Medicine 01.06.1979
Oxford University Press
BMJ Group
Subjects
Child
Child, Preschool
Deafness - genetics
Diabetes Insipidus - genetics
Diabetes Mellitus, Type 1 - genetics
Female
Humans
Hydronephrosis - diagnostic imaging
Hydronephrosis - genetics
Optic Atrophy - genetics
Pedigree
Polyuria - genetics
Radiography
Syndrome
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Summary:Two Iraqi sisters and a female cousin developed diabetes insipidus (DI), diabetes mellitus (DM), optic atrophy (OA), and deafness (D), (the 'DIDMOAD' syndrome) before the age of 12 years. One girl exhibited all the features of this disease complex only 3 months after an unusually late onset of recognizable symptoms at 11 years 9 months. Another girl died suddenly and unexpectedly. This family study illustrates the recessive inheritance pattern of the syndrome.
Bibliography:PMID:482181
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ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.55.644.377