Aplasia and leukaemia following chloroquine therapy

Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed...

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Bibliographic Details
Published inPostgraduate medical journal Vol. 54; no. 628; pp. 108 - 112
Main Authors Nagaratnam, N., Chetiyawardana, A. D., Rajiyah, S.
Format Journal Article
LanguageEnglish
Published England The Fellowship of Postgraduate Medicine 01.02.1978
Oxford University Press
BMJ Group
Subjects
Adult
Anemia, Aplastic - chemically induced
Bone Marrow - pathology
Chloroquine - adverse effects
Chloroquine - therapeutic use
Female
Humans
Leukemia, Myeloid, Acute - chemically induced
Malaria - drug therapy
Male
Middle Aged
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Summary:Three patients with aplastic anaemia following chloroquine therapy are described. In two, chloroquine had been administered in large doses over a long period. One of them subsequently developed acute myeloblastic leukaemia. The third received only a small dose and pancytopenia with aplasia followed three weeks after ingestion of the drug. The mechanism(s) of chloroquine-induced marrow injury is not known. A parallel to chloramphenicol-induced blood dyscrasias is drawn, but remains unproved.
Bibliography:PMID:273209
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href:postgradmedj-54-108.pdf
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ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.54.628.108