Albumin Excretion as a Measure of Glomerular Dysfunction in Children

• Published in: Archives of Disease in Childhood Vol. 45; no. 242; pp. 496 - 501
• Main Authors: Barratt, T. M., McLaine, P. N., Soothill, J. F.
• Format: Journal Article Book Review
• Language: English
• Published: England BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01.08.1970; BMJ Publishing Group LTD
• Subjects: Albuminuria; Body size; Child; Creatinine - urine; Cyclophosphamide - therapeutic use; Excretion; Female; Glomerular Filtration Rate; Glomerulonephritis - drug therapy; Humans; Kidney Diseases - urine; Male; Metabolic Clearance Rate; Review; Statistics as Topic
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/adc.45.242.496

The urine albumin/creatinine concentration ratio (UA/UC) and the albumin excretion rate per unit weight (UAV/Wt) have been compared with the theoretically ideal parameter for measuring glomerular damage, clearance of albumin/clearance of creatinine (CA/CC), using a simple sensitive immunochemical technique for albumin. It is shown that UA/UC on random urine specimens can be as satisfactorily used to predict CA/CC as UAV/Wt. Normal data over a wide range of body size of this simple parameter are presented; higher values in the newborn reflect increased permeability of the neonatal glomerulus.