Hormonal and metabolic substrate status in response to exercise in men of different phenotype

• Published in: Endocrine Connections Vol. 8; no. 7; pp. 814 - 821
• Main Authors: Chycki, J, Zajac, A, Michalczyk, M, Maszczyk, A, Langfort, J
• Format: Journal Article
• Language: English
• Published: England Bioscientifica Ltd 01.07.2019; Bioscientifica
• Subjects: endocrine response; exercise metabolism; free fatty acid metabolism; lipolytic hormones; phenotype; phenotype; exercise metabolism; free fatty acid metabolism; endocrine response; lipolytic hormones
• ISSN: 2049-3614; 2049-3614
• DOI: 10.1530/EC-19-0216

Objectives The present study verified the effect of moderate-to-high-intensity aerobic exercise on the endocrine response profile and adipose tissue in young healthy men with different phenotype characteristics. Design Eighteen men were divided into three experimental groups with defined body components and specific physical fitness: Endurance phenotype – EP (n = 6; low body mass; low fat content; aerobic endurance trained), Athletic phenotype – AP (n = 6; high body mass; low fat content, resistance trained), Obesity phenotype – OP (n = 6; high body mass; high fat content, untrained). Methods The participants performed an progressive exercise protocol on a treadmill (30% VO2max, 50% VO2max, 70% VO2max), separated by 45 s of passive rest for blood collection. Results Plasma glucose oxidation increased in relation to exercise intensity, but to a greater extent in the AP group. The free fatty acids’ plasma level decreased with a rise in exercise intensity, but with different kinetics in particular phenotypes. Plasma growth hormone increased after the cessation of exercise and was significantly higher in all groups 45 min into recovery compared to resting values. Plasma insulin decreased during exercise in all groups, but in the OP, the decrease was blunted. Conclusions The results indicate that the rate of lipolysis, hormonal and metabolic response to aerobic exercise depends on the individuals’ phenotype. Thus, exercise type, duration and intensity have to be strictly individualized in relation to phenotype in order to reach optimal metabolic benefits.