Postprandial lipemia is modified by the presence of the polymorphism present in the exon 1 variant at the SR-BI gene locus

• Published in: Journal of molecular endocrinology Vol. 32; no. 1; pp. 237 - 245
• Main Authors: Perez-Martinez, P, Lopez-Miranda, J, Ordovas, JM, Bellido, C, Marin, C, Gomez, P, Paniagua, JA, Moreno, JA, Fuentes, F, Perez-Jimenez, F
• Format: Journal Article
• Language: English
• Published: England BioScientifica 01.02.2004
• Subjects: Adult; CD36 Antigens; Cholesterol, LDL - analysis; Cholesterol, LDL - blood; Dietary Fats - metabolism; Fatty Acids - pharmacology; Heterozygote; Homozygote; Humans; Lipoproteins - analysis; Lipoproteins - blood; Male; Polymorphism, Genetic - genetics; Postprandial Period - physiology; Receptors, Immunologic - genetics; Receptors, Scavenger; Scavenger Receptors, Class B; Triglycerides - analysis; Triglycerides - blood; Vitamin A - analogs & derivatives; Vitamin A - analysis; Vitamin A - blood; Vitamin A - pharmacology
• ISSN: 0952-5041; 1479-6813
• DOI: 10.1677/jme.0.0320237

It has recently been reported that carriers of the less common allele at the scavenger receptor class B type I (SR-BI) exon 1 polymorphism are more susceptible to the presence of saturated fatty acid in the diet because of a greater increase in LDL cholesterol. Our aim was to determine if this polymorphism could also influence postprandial lipoprotein metabolism, because the SR-BI has been described as a possible mediator in the intestinal absorption of triacylglycerols. Forty-seven normolipidemic volunteers who were homozygous for the E3 allele at the APOE gene were selected [37 homozygous for the common genotype (1/1) at the SR-BI exon 1 polymorphism and 10 heterozygous (1/2)]. They were given a fat-rich meal containing 1 g fat and 7 mg cholesterol per kg body weight and vitamin A 60,000 IU/m2 body surface. Fat accounted for 60% of calories, and protein and carbohydrates accounted for 15% and 25% of energy respectively. Blood samples were taken at time 0, every 1 h until 6 h, and every 2.5 h until 11 h. Total cholesterol and triacylglycerols in plasma, and cholesterol, triacylglycerols and retinyl palmitate in triacylglycerol-rich lipoproteins (large and small triacylglycerol-rich lipoproteins) were determined. Postprandial responses for triacylglycerols and retinyl palmitate in small triacylglycerol-rich lipoproteins were higher in 1/1 individuals than in 1/2 individuals. No other significant differences were noted. Our data show that the presence of the genotype 1/2 is associated with a lower postprandial lipemic response.