Protein NMR-Based Screening in Drug Discovery

Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.

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Bibliographic Details
Published inCurrent pharmaceutical design Vol. 12; no. 31; pp. 3963 - 3972
Main Authors Zartler, E R, Shapiro, M J
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.11.2006
Subjects
Chemistry, Pharmaceutical
Isotope Labeling - methods
Ligands
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Nucleic Acids - chemistry
Nucleic Acids - metabolism
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
Protein Binding
Protein Conformation
Proteins - chemistry
Proteins - metabolism
Structure-Activity Relationship
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Summary:Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
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ISSN:1381-6128
1873-4286
DOI:10.2174/138161206778743619