Congenital cytomegalovirus infection in twin pregnancy

Cytomegalovirus (CMV) infection is one of the preeminent congenital viral infections, and despite its potential morbidity, uncertainty about its physiopathology, prevention and treatment remains until now. We report a case of a dichorionic and diamniotic twin pregnancy in which only one of the fetus...

Full description

Saved in:
Bibliographic Details
Published inBMJ case reports Vol. 14; no. 7; p. e242712
Main Authors Carvalho, Ana Araújo, Silva, Cláudia B, Martins, Maria Luísa, Santos, Gonçalo Cassiano
Format Journal Article
LanguageEnglish
Published England BMJ Publishing Group LTD 12.07.2021
BMJ Publishing Group
Subjects
Age
Amniotic fluid
Antiviral drugs
Apgar score
Asymptomatic
Blood tests
Case Report
Case reports
Cysts
Cytomegalovirus
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - drug therapy
Female
Fetuses
Histopathology
Humans
Infant, Newborn
Infections
Infectious Disease Transmission, Vertical
Intellectual disabilities
Medical screening
Morphology
Neutropenia
Otolaryngology
Placenta
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - drug therapy
Pregnancy, Twin
Serology
Thrombocytopenia
Ultrasonic imaging
Viral infections
materno-fetal medicine
congenital disorders
infectious diseases
Online AccessGet full text

Cover

More Information
Summary:Cytomegalovirus (CMV) infection is one of the preeminent congenital viral infections, and despite its potential morbidity, uncertainty about its physiopathology, prevention and treatment remains until now. We report a case of a dichorionic and diamniotic twin pregnancy in which only one of the fetus had signs of being affected. The first twin had prenatal diagnosis of intrauterine growth restriction and hyperechogenic bowel, attributable to CMV infection, while there was no evidence of infection of the second one. Prenatal treatment was done with maternal administration of valacyclovir and postnatal treatment of the infected newborn with oral valganciclovir with normal neurodevelopment assessment at 12 months corrected age. In this case, maternal CMV infection was not equally transmitted to both fetuses, suggesting that there may be intrinsic fetal and placental factors influencing both transmission and the clinical features of the infection.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2021-242712